Kombinatorische Chemie

Die kombinatorische Chemie versucht, durch Kombination und Variation verschiedener Reste an einem Grundgerüst eine Vielzahl von Molekülen herzustellen, aus der diejenigen mit den gewünschten bzw. optimierten Eigenschaften herausgesucht werden müssen. Zur Synthese werden meistens Roboter und standardisierte Reaktionsabläufe genutzt.

Anwendungen finden sich vor allem in der medizinische Chemie bzw. in der Pharmakologie. Dort werden mit Hilfe der kombinatorischen Chemie neue Wirkstoffe gefunden oder optimiert. Während in der Anfangsphase Anfang der 1980er Jahre versucht wurde, eine möglichst große Zahl von Verbindungen, sogenannte Bibliotheken, herzustellen, ging der Trend später zur Synthese von aufgereinigten und gut charakterisierten Einzelverbindungen. Der Übergang zur Parallelsynthese wurde damit fließend.

Literatur

  • Gerhard Klebe: Wirkstoffdesign: Entwurf und Wirkung von Arzneistoffen. 2. Auflage. Spektrum, Akad. Verl, Heidelberg 2009, ISBN 978-3-8274-2046-6, Kapitel Kombinatorik: Chemie mit großen Zahlen.

Read other articles:

Ermentarius Tornusiensis

Artikel ini sebatang kara, artinya tidak ada artikel lain yang memiliki pranala balik ke halaman ini.Bantulah menambah pranala ke artikel ini dari artikel yang berhubungan atau coba peralatan pencari pranala.Tag ini diberikan pada Oktober 2022. Ermentar dari Noirmoutier, juga disebut Ermentarius Tornusiensis (wafat pertengahan 860-an), merupakan seorang biarawan dan sejarawan biara Saint-Philibert de Tournus. Ia menulis tawarikh prosa nyata, De translationibus et miraculis sancti Filiberti, m...

 

Первородный грех

Об экономическом термине см. Первородный грех (экономика). ХристианствоБиблия Ветхий Завет Новый Завет Евангелие Десять заповедей Нагорная проповедь Апокрифы Бог, Троица Бог Отец Иисус Христос Святой Дух История христианства Апостолы Хронология христианства Ран�...

 

Peter Handke

Austrian Nobel laureate novelist (born 1942) Peter HandkeHandke in 2006Born (1942-12-06) 6 December 1942 (age 81)Griffen, AustriaOccupation Novelist Playwright EducationUniversity of GrazNotable works Offending the Audience Kaspar A Sorrow Beyond Dreams Repetition Notable awards Georg Büchner Prize (1973) Vilenica International Literary Prize (1987) Brothers Karic award for literature (2000) International Ibsen Award (2014) Nobel Prize in Literature (2019) SpouseSophie Semin (since 1995...

Invasi Jin Akhir ke Joseon

Invasi Jin Akhir ke JoseonBagian dari Konflik Korea–Jurchen, Penaklukan Ming oleh QingTanggalJanuari - 3 Maret 1627LokasiSemenanjung Korea UtaraHasil Kemenangan Jin AkhirPihak terlibat JoseonDinasti Ming Jin AkhirTokoh dan pemimpin Joseon: Jeong Bong-suYi RipJang ManKim Sang-yong Dinasti Ming:Mao Wenlong Amin Gang Hong-ripJirgalangAjigeYotoLi Yongfang 李永芳Kekuatan Tidak diketahui 30.000[1]Korban Tidak diketahui Tidak diketahui lbsPeralihan dari Ming ke Qing Fushun Qinghe Sarhū...

 

Geomembrane

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.Find sources: Geomembrane – news · newspapers · books · scholar · JSTOR (March 2019) (Learn how and when to remove this template message) A geomembrane is very low permeability synthetic membrane liner or barrier used with any geotechnical engineering related material so as ...

 

Fawley A.F.C.

Association football club in England Football clubFawleyFull nameFawley Association Football ClubNickname(s)The OilersFounded1923GroundWaterside Sports & Social Club, HolburyChairmanKevin MitchellManagerLee Shepherd and Simon EagleLeagueWessex League Division One2022–23Wessex League Division One, 13th of 20 Home colours Away colours Fawley Association Football Club is a football club based in Fawley, near Southampton, in Hampshire, England. They are currently members of Wessex League Di...

Pontiac (Michigan)

Questa voce sull'argomento centri abitati del Michigan è solo un abbozzo. Contribuisci a migliorarla secondo le convenzioni di Wikipedia. Segui i suggerimenti del progetto di riferimento. Pontiaccity(EN) Pontiac, Michigan Pontiac – Veduta LocalizzazioneStato Stati Uniti Stato federato Michigan ConteaOakland AmministrazioneSindacoClarence E. Phillips TerritorioCoordinate42°38′46″N 83°17′33″W / 42.646111°N 83.2925°W42.646111; -83.2925 (Pontiac)Co...

 

Hr2-kultur

You can help expand this article with text translated from the corresponding article in German. (August 2023) Click [show] for important translation instructions. Machine translation, like DeepL or Google Translate, is a useful starting point for translations, but translators must revise errors as necessary and confirm that the translation is accurate, rather than simply copy-pasting machine-translated text into the English Wikipedia. Consider adding a topic to this template: there are a...

 

Agatha Biddle

Métis fur trader and community leader Agatha BiddleBorn1797 Died1873  (aged 75–76)Mackinac Island OccupationFur trader, community organizer, philanthropist AwardsMichigan Women's Hall of Fame (2018)  Agatha de LaVigne Biddle (1797–1873) was a woman of Odawa and French heritage, who primarily identified with her Odawa kin.[1] She resided on Mackinac Island during the fur trade era and after.[1] She acted as a partner with her husband in running...

America Ferrera

Pour les articles homonymes, voir Ferrera (homonymie). America Ferrera America Ferrera au Festival de Cannes 2014. Données clés Nom de naissance America Georgina Ferrera Naissance 18 avril 1984 (40 ans)Los Angeles, Californie (États-Unis) Nationalité Américaine Profession ActriceProductriceRéalisatrice Films notables Quatre filles et un jeanLa guerre des pèresCadenceDragons (série de films)End of WatchBarbie Séries notables Ugly BettyThe Good WifeSuperstore modifier America Geo...

 

Kirstjen Nielsen

Kirstjen Nielsen 6° Segretario della Sicurezza Interna degli Stati Uniti d'AmericaDurata mandato6 dicembre 2017 –11 aprile 2019 PresidenteDonald Trump PredecessoreJohn F. Kelly SuccessoreAlejandro Mayorkas (2021) Dati generaliPartito politicoIndipendente Titolo di studioLaurea in scienze politiche(Università di Georgetown)Laurea in giurisprudenza(Università della Virginia) UniversitàUniversità di GeorgetownUniversità della Virginia Kirstjen Michele Nielsen...

 

Rafle de la rue Sainte-Catherine

Rafle de la rue Sainte-Catherine Lyon, rue Sainte-Catherine, plaque commémorative Type Rafle (Shoah en France) Pays France Localisation Lyon Organisateur  Reich allemand Date 9 février 1943 Participant(s) Gestapo de Lyon et décidée par Klaus Barbie Répression Arrestations 86 Juifs (62 hommes et 24 femmes) modifier  La rafle de la rue Sainte-Catherine est une rafle décidée par Klaus Barbie et organisée par la Gestapo lyonnaise, qui s'est déroulée le 9 février 1943 au 12 d...

Raymond Firth

Economic anthropologist SirRaymond FirthCNZM FRAI FBAFirth c. 1965Born(1901-03-25)25 March 1901Auckland, New ZealandDied22 February 2002(2002-02-22) (aged 100)London, EnglandAlma materAuckland University College (BA, MA, Dipl)London School of Economics (PhD)Spouse Rosemary Upcott ​ ​(m. 1936; died 2001)​Scientific careerFieldsEthnologyThesisEconomic organisation of Polynesian societies: wealth and work of the Maori (1927...

 

ستان بوش

ستان بوش (بالإنجليزية: Stan Bush)‏    معلومات شخصية الميلاد 10 يوليو 1953 (71 سنة)  أورلاندو  مواطنة الولايات المتحدة  الحياة العملية المهنة مغني،  وعازف قيثارة،  ومغن مؤلف،  وملحن  المواقع الموقع الموقع الرسمي  IMDB صفحته على IMDB[1][2]  تعديل مصدري - ت�...

 

معهد الدفاع الجوي للقوات المسلحة (مصر)

معهد الدفاع الجوي الدولة  مصر الولاء  مصر النوع معهد الدور تعليمي جزء من القوات المسلحة المصرية تعديل مصدري - تعديل   معهد الدفاع الجوي هو إحدى معاهد القوات المسلحة المصرية والذي يقوم بتأهيل وإعداد الضباط من خريجي كلية الدفاع الجوي لتولي الوظائف القيادية المختلفة،...

Thornford

Village in Dorset, England Human settlement in EnglandThornfordThornfordLocation within DorsetPopulation830 [1]OS grid referenceST604132Unitary authorityDorsetShire countyDorsetRegionSouth WestCountryEnglandSovereign stateUnited KingdomPost townSHERBORNEPostcode districtDT9Dialling code01935PoliceDorsetFireDorset and WiltshireAmbulanceSouth Western UK ParliamentWest Dorset List of places UK England Dorset 50°55′00″N 2°33′49″Wþ...

 

Head of the River Race

Annual rowing event for eights in London Head of the River RaceCrews racing under Hammersmith Bridge at HORR 2005FrequencyAnnualLocation(s)Championship Course, River Thames in London, EnglandYears active1925–1936, 1938–1939, 1946–2003, 2005–2006, 2008–2012, 2014–2016, 2018–2019, 2022–Previous event18 March 2023Next event23 March 2024Participantsapproximately 340 to 420 crewsOrganised byHoRR Committee, British Rowing[a]Websitewww.horr.co.ukLatest Head Pennant winning cr...

 

Іркутський державний технічний університет

Іркутський державний технічний університетИРНИТУ|акредитація 52°15′46″ пн. ш. 104°15′42″ сх. д. / 52.26277778002777552° пн. ш. 104.26194444002777573° сх. д. / 52.26277778002777552; 104.26194444002777573Координати: 52°15′46″ пн. ш. 104°15′42″ сх. д. / 52.26277778002777552° пн. �...

Lehigh University

Private university in Bethlehem, Pennsylvania, US Lehigh UniversityMottoHomo minister et interpres naturae (Latin)Motto in EnglishMan, the servant and interpreter of natureTypePrivate research universityEstablishedJuly 27, 1865; 158 years ago (1865-07-27)FounderAsa PackerAccreditationMSCHEReligious affiliationNonsectarian; historically Episcopal ChurchAcademic affiliationsNAICUORAUSpace-grantEndowment$1.37 billion (2020)[1]PresidentJoseph J. HelbleProvostNathan ...

 

Kastil Horben

Artikel atau bagian mungkin perlu ditulis ulang agar sesuai dengan standar kualitas Wikipedia. Anda dapat membantu memperbaikinya. Halaman pembicaraan dari artikel ini mungkin berisi beberapa saran. Kastil HorbenBeinwil (Freiamt) Kastil HorbenKastil HorbenKoordinat47°13′12.29″N 8°19′36.34″E / 47.2200806°N 8.3267611°E / 47.2200806; 8.3267611KodeCH-AGTinggi818 m above the seaInformasi situsKondisidilestarikanSejarah situsDibangun1700 Kapel Horb...