Matrixový protein

Matrixový protein retroviru myší leukemie (MLV)

Matrixový protein (MA) je strukturní protein mnohých virů, který se nachází pod virovým obalem a spojuje ho s kapsidou.[1] Má různou strukturu a poměrně široké spektrum funkcí. Najdeme ho namátkou u rhabdovirů, filovirů, paramyxovirů, ortomyxovirů, arenavirů či retrovirů.[2]

Matrixový protein retrovirů

Retrovirový matrix protein (u HIV známý jako p17) je jedním z produktů gag genu, nachází se na jeho N-terminální části. Po vystřihnutí z gag polyproteinu se MA uchytí spodní strany virového obalu, a to pomocí myristoylového zbytku navázaného na glycin proteinu. Jedná se tedy o periferní membránový protein. U některých jednoduchých retrovirů však matrixový protein zcela chybí.[2]

Reference

  1. ↑ MAHY, Brian W J; VAN REGENMORTEL, Marc H V. Desk Encyclopedia of General Virology. [s.l.]: Elsevier, 2010. ISBN 978-0-12-375146-1. 
  2. ↑ a b C K Navaratnarajah, R Warrier, R J Kuhn. Assembly of Viruses: Enveloped Particles. In: Mahy, Brian W. J.; Regenmortel, Marc H. V. Encyclopedia of Virology. 3. vyd. [s.l.]: Elsevier, 2008. ISBN 978-0-12-373935-3.

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