Adipokin

Adipokiny (adipocytokiny) jsou proteiny (bílkoviny), které jsou tvořeny tukovými buňkami (adipocyty). Tyto látky jsou vyplavovány do krevního oběhu a ovlivňují početné funkce organismu – příjem potravy, výdej energie, rozvoj zánětu, reakce imunitního systému, rozvoj patologických komplikací v oblasti kardiovaskulárního systému (ateroskleróza, infarkt myokardu) nebo funkci pohlavního systému.

Historie

Tukové buňky byly dlouho považovány za metabolicky neaktivní, sloužící pouze jako rezervoár přebytečně přijaté energie. V roce 1994 byly objeveny první látky (TNFα a leptin), které jsou adipocyty produkovány. V současné době je známo několik desítek proteinů, které můžeme mezi adipokiny řadit.

Zástupci

Současnost a potenciál

V současné době probíhají intenzivní studie, které zkoumají adipokiny a jejich vliv na organismus. Poznání funkcí a jejich ovlivnění by mohlo do budoucna přinést efektivní léčbu obezity a stavů s ní spojených.

Literatura

  • Misra A., Vikram N. K. Clinical and Pathophysiological Consequences of Abdominal Adiposity and Abdominal Adipose Tissue Depots. Nutrition, 2003, 19: 457-466.
  • Miner J. L. The adipocyte as an endocrine cell. J, Anim. Sci, 2004, 82: 935-941.
  • Klener I. Leptin. Archivováno 18. 1. 2008 na Wayback Machine.

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