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B2M
Estructures disponibles
PDB	Cerca ortòloga: PDBe RCSB
Llista de codis id de PDB
	1A1M, 1A1N, 1A1O, 1A6Z, 1A9B, 1A9E, 1AGB, 1AGC, 1AGD, 1AGE, 1AGF, 1AKJ, 1AO7, 1B0G, 1B0R, 1BD2, 1C16, 1CE6, 1DE4, 1DUY, 1DUZ, 1E27, 1E28, 1EEY, 1EEZ, 1EFX, 1EXU, 1GZP, 1GZQ, 1HHG, 1HHH, 1HHI, 1HHJ, 1HHK, 1HLA, 1HSA, 1HSB, 1I1F, 1I1Y, 1I4F, 1I7R, 1I7T, 1I7U, 1IM3, 1IM9, 1JF1, 1JGD, 1JGE, 1JHT, 1JNJ, 1K5N, 1KPR, 1KTL, 1LDS, 1LP9, 1M05, 1M6O, 1MHE, 1MI5, 1OF2, 1OGA, 1OGT, 1ONQ, 1PY4, 1Q94, 1QEW, 1QLF, 1QQD, 1QR1, 1QRN, 1QSE, 1QSF, 1QVO, 1R3H, 1S9W, 1S9X, 1S9Y, 1SYS, 1SYV, 1TMC, 1TVB, 1TVH, 1UQS, 1UXS, 1UXW, 1VGK, 1W0V, 1W0W, 1W72, 1X7Q, 1XH3, 1XR8, 1XR9, 1XZ0, 1YDP, 1YPZ, 1ZHK, 1ZHL, 1ZS8, 1ZSD, 1ZT4, 1ZVS, 2A83, 2AK4, 2AV7, 2AXF, 2AXG, 2BCK, 2BNQ, 2BNR, 2BSR, 2BSS, 2BST, 2BVO, 2BVP, 2BVQ, 2C7U, 2CII, 2CIK, 2CLR, 2D31, 2D4D, 2D4F, 2DYP, 2E8D, 2ESV, 2F53, 2F54, 2F74, 2F8O, 2GIT, 2GJ6, 2GT9, 2GTW, 2GTZ, 2GUO, 2H26, 2H6P, 2HJL, 2HLA, 2HN7, 2J8U, 2JCC, 2NW3, 2NX5, 2P5E, 2P5W, 2PO6, 2PYE, 2RFX, 2UWE, 2V2W, 2V2X, 2VB5, 2VLJ, 2VLK, 2VLL, 2VLR, 2X4N, 2X4O, 2X4P, 2X4Q, 2X4R, 2X4S, 2X4T, 2X4U, 2X70, 2X89, 2XKS, 2XKU, 2XPG, 2YPK, 2YPL, 2YXF, 2Z9T, 3AM8, 3B3I, 3B6S, 3BGM, 3BH8, 3BH9, 3BHB, 3BO8, 3BP4, 3BP7, 3BVN, 3BW9, 3BWA, 3BXN, 3BZE, 3BZF, 3C9N, 3CDG, 3CII, 3CIQ, 3CZF, 3D18, 3D25, 3D2U, 3D39, 3D3V, 3DBX, 3DHJ, 3DHM, 3DTX, 3DXA, 3EKC, 3FFC, 3FQN, 3FQR, 3FQT, 3FQU, 3FQW, 3FQX, 3FT2, 3FT3, 3FT4, 3GIV, 3GJF, 3GSN, 3GSO, 3GSQ, 3GSR, 3GSU, 3GSV, 3GSW, 3GSX, 3H7B, 3H9H, 3H9S, 3HAE, 3HCV, 3HG1, 3HLA, 3HPJ, 3HUJ, 3I6G, 3I6K, 3I6L, 3IB4, 3IXA, 3JTS, 3KLA, 3KPO, 3KPR, 3KPS, 3KWW, 3KXF, 3KYN, 3KYO, 3L3D, 3L3G, 3L3I, 3L3J, 3L3K, 3LKN, 3LKO, 3LKP, 3LKQ, 3LKR, 3LKS, 3LN4, 3LN5, 3LOW, 3LV3, 3M17, 3M1B, 3MGO, 3MGT, 3MR9, 3MRB, 3MRC, 3MRD, 3MRE, 3MRF, 3MRG, 3MRH, 3MRI, 3MRJ, 3MRK, 3MRL, 3MRM, 3MRN, 3MRO, 3MRP, 3MRQ, 3MRR, 3MV7, 3MV8, 3MV9, 3MYJ, 3MYZ, 3MZT, 3NA4, 3NFN, 3O3A, 3O3B, 3O3D, 3O3E, 3O4L, 3OX8, 3OXR, 3OXS, 3PWJ, 3PWL, 3PWN, 3PWP, 3QDA, 3QDG, 3QDJ, 3QDM, 3QEQ, 3QFD, 3QFJ, 3QZW, 3RL1, 3RWJ, 3S6C, 3SDX, 3SJV, 3SKM, 3SKO, 3SPV, 3T8X, 3TID, 3TIE, 3TLR, 3TM6, 3TO2, 3TZV, 3U0P, 3UPR, 3UTQ, 3UTS, 3UTT, 3V5D, 3V5H, 3V5K, 3VCL, 3VFR, 3VFS, 3VFT, 3VFU, 3VFV, 3VFW, 3VH8, 3VRI, 3VRJ, 3VWJ, 3VWK, 3W39, 4E0K, 4E0L, 4E5X, 4EN3, 4EUP, 4F7M, 4F7P, 4F7T, 4FTV, 4FXL, 4G8G, 4G8I, 4G9D, 4G9F, 4GKS, 4GUP, 4HKJ, 4I4W, 4JFD, 4JFE, 4JFF, 4JFO, 4JFP, 4JFQ, 4JQX, 4JRX, 4JRY, 4K7F, 4KDT, 4L4T, 4L4V, 1CG9, 1N2R, 1P7Q, 1S8D, 1T1W, 1T1X, 1T1Y, 1T1Z, 1T20, 1T21, 1T22, 2AV1, 2FYY, 2FZ3, 2HJK, 3DX6, 3DX7, 3DX8, 3KPL, 3KPM, 3KPN, 3KPP, 3KPQ, 3LOZ, 3OV6, 3REW, 3RL2, 3VXM, 3VXN, 3VXO, 3VXP, 3VXR, 3VXS, 3VXU, 3W0W, 3WL9, 3WLB, 3WUW, 3X11, 3X12, 3X13, 3X14, 4GKN, 4HWZ, 4HX1, 4I48, 4K71, 4L29, 4L3C, 4L3E, 4LCW, 4LCY, 4LHU, 4LNR, 4M8V, 4MJ5, 4MJ6, 4MJI, 4MNQ, 4N0F, 4N0U, 4N8V, 4NNX, 4NNY, 4NO0, 4NO2, 4NO3, 4NO5, 4NQC, 4NQD, 4NQE, 4NQV, 4NQX, 4NT6, 4O2C, 4O2E, 4O2F, 4ONO, 4PJ5, 4PJ7, 4PJ8, 4PJ9, 4PJA, 4PJB, 4PJC, 4PJD, 4PJE, 4PJF, 4PJG, 4PJH, 4PJI, 4PJX, 4PR5, 4PRA, 4PRB, 4PRD, 4PRE, 4PRH, 4PRI, 4PRN, 4PRP, 4QOK, 4QRP, 4QRQ, 4QRR, 4QRS, 4QRT, 4QRU, 4U1H, 4U1I, 4U1J, 4U1K, 4U1L, 4U1M, 4U1N, 4U1S, 4U6X, 4U6Y, 4UQ2, 4UQ3, 4WJ5, 4WO4, 4WU5, 4WU7, 4X6C, 4X6D, 4X6E, 4X6F, 4XXC, 4WDI, 4Z76, 4Z77, 4Z78, 4R9H, 4RA3, 4RAH, 5D2L, 5D2N, 4WW2, 5DEG, 4RMT, 5DEF, 4RMW, 4RMV, 4RMR, 5D7J, 4RMQ, 4RMS, 4WWK, 5BXF, 5D5M, 5D7L, 4RMU, 4WUU, 5D7I, 5EU5, 5EO0, 5EO1, 5EU4, 5BRZ, 5EU6, 5BS0, 5EU3, 5C9J, 5D9S, 5HGA, 5C0D, 5C0B, 5C0I, 5C0A, 5B38, 5E9D, 5B39, 5C0H, 5HHN, 5HGD, 5C08, 5CFH, 5CKG, 4ZEZ, 5C0C, 5HGH, 5C0J, 5HHQ, 5DDH, 5HHM, 5HGB, 5C09, 5HYJ, 5CKA, 5C07, 5HHP, 5C0G, 5C0F, 5HHO, 5C0E
Identificadors
Àlies	B2M (HUGO), entrez:567, IMD43, beta-2-microglobulin, Β2 microglobulin
Identif. externs	OMIM: 109700 MGI: 88127 HomoloGene: 2987 GeneCards: B2M OMA: B2M - orthologs
Malalties relacionades genèticament
	familial visceral amyloidosis
Localització del gen (humà)
	Cromosoma: 15 (humà)
Fi	44.718.851 bp
Localització del gen (ratolí)
	Cromosoma: 2 (ratolí)
Fi	121.983.564 bp
Patró d'expressió d'ARN
	Més explicacions
	leucòcit; ; monòcit; ; vesícula biliar; ; granulòcit; ; apèndix vermiforme; ; gangli limfàtic; ; right lung ; ; melsa; ; upper lobe of left lung ; ; recte;
	Més explicacions
	vesícula seminal; ; gangli limfàtic; ; glàndula submandibular ; ; mesenteric lymph nodes ; ; right lung ; ; teixit adipós blanc; ; right lung lobe ; ; melsa; ; greix subcutani; ; tim;
	Més referències a dades d'expressió
	; ;
	Més referències a dades d'expressió
Ontologia genètica
Funció molecular	unió proteica ; unió de proteïnes idèntica ;
Component cel·lular	HFE-transferrin receptor complex ; aparell de Golgi ; phagocytic vesicle membrane ; early endosome membrane ; endoplasmic reticulum lumen ; membrana ; focal adhesion ; Golgi membrane ; membrana plasmàtica ; regió extracel·lular ; MHC class I protein complex ; ER to Golgi transport vesicle membrane ; early endosome lumen ; exosoma extracel·lular ; external side of plasma membrane ; extracel·lular ; citosol ; superfície cel·lular ; specific granule lumen ; recycling endosome membrane ; tertiary granule lumen ; MHC class I peptide loading complex ;
Procés biològic	positive regulation of receptor-mediated endocytosis ; cellular response to iron ion ; response to cadmium ion ; negative regulation of receptor binding ; negative regulation of neuron projection development ; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent ; T cell differentiation in thymus ; procés del sistema immunitari ; interferon-gamma-mediated signaling pathway ; antigen processing and presentation of peptide antigen via MHC class I ; iron ion homeostasis ; positive regulation of T cell mediated cytotoxicity ; mitigation of host defenses by virus ; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent ; regulation of membrane depolarization ; antigen processing and presentation of endogenous peptide antigen via MHC class I ; positive regulation of ferrous iron binding ; positive regulation of transferrin receptor binding ; retina homeostasis ; positive regulation of T cell cytokine production ; protein refolding ; resposta immunitària ; regulation of immune response ; positive regulation of receptor binding ; positive regulation of protein binding ; sistema immunitari innat ; cellular response to lipopolysaccharide ; response to molecule of bacterial origin ; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent ; iron ion transport ; neutrophil degranulation ; regulation of erythrocyte differentiation ; cellular response to iron(III) ion ; antimicrobial humoral immune response mediated by antimicrobial peptide ; positive regulation of iron ion import across plasma membrane ; regulation of iron ion transport ;
	Fonts: Amigo / QuickGO
Ortòlegs
	567
	12010
	ENSG00000166710; ENSG00000273686
	ENSMUSG00000060802
	P61769
	P01887
	NM_004048
	NM_009735
	NP_004039
	NP_033865
	Wikidata
Veure/Editar gen humà	Veure/Editar gen del ratolí

La β₂ microglobulina (B2M) és un component de les molècules MHC classe I. Les molècules MHC de classe I tenen proteïnes α₁, α₂ i α₃ que estan presents a totes les cèl·lules nucleades (excloent els glòbuls vermells).^[6]^[7] En humans, la proteïna^[8] de la microglobulina β₂ està codificada pel gen B2M.^[7]^[9]

Referències

↑ «Malalties que s'associen genèticament amb B2M, vegeu/editeu les referències a wikidata».
↑ ^2,0 ^2,1 ^2,2 ENSG00000273686 GRCh38: Ensembl release 89: ENSG00000166710, ENSG00000273686 - Ensembl, May 2017
↑ ^3,0 ^3,1 ^3,2 GRCm38: Ensembl release 89: ENSMUSG00000060802 – Ensembl, May 2017
↑ «Human PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ «Mouse PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ «Entrez Gene: Beta-2-microglobulin».
↑ ^7,0 ^7,1 «The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit». Journal of Immunology, 139, 9, 11-1987, pàg. 3132–8. DOI: 10.4049/jimmunol.139.9.3132. PMID: 3312414.
↑ «The complete amino acid sequence of beta 2-microglobulin». Biochemistry, 12, 24, 11-1973, pàg. 4811–22. DOI: 10.1021/bi00748a001. PMID: 4586824.
↑ «Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin». Proceedings of the National Academy of Sciences of the United States of America, 78, 11, 11-1981, pàg. 6613–7. Bibcode: 1981PNAS...78.6613S. DOI: 10.1073/pnas.78.11.6613. PMC: 349099. PMID: 6171820.

[1] «Malalties que s'associen genèticament amb B2M, vegeu/editeu les referències a wikidata».

[refGRCh38Ensembl-2] 2,0 ^2,1 ^2,2 ENSG00000273686 GRCh38: Ensembl release 89: ENSG00000166710, ENSG00000273686 - Ensembl, May 2017

[refGRCm38Ensembl-3] 3,0 ^3,1 ^3,2 GRCm38: Ensembl release 89: ENSMUSG00000060802 – Ensembl, May 2017

[4] «Human PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] «Mouse PubMed Reference:». National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez_567-6] «Entrez Gene: Beta-2-microglobulin».

[pmid3312414-7] 7,0 ^7,1 «The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit». Journal of Immunology, 139, 9, 11-1987, pàg. 3132–8. DOI: 10.4049/jimmunol.139.9.3132. PMID: 3312414.

[pmid4586824-8] «The complete amino acid sequence of beta 2-microglobulin». Biochemistry, 12, 24, 11-1973, pàg. 4811–22. DOI: 10.1021/bi00748a001. PMID: 4586824.

[pmid6171820-9] «Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin». Proceedings of the National Academy of Sciences of the United States of America, 78, 11, 11-1981, pàg. 6613–7. Bibcode: 1981PNAS...78.6613S. DOI: 10.1073/pnas.78.11.6613. PMC: 349099. PMID: 6171820.

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Beta-2 microglobulina

Referències

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