Y-27632

Y-27632
Općenito
Hemijski spojY-27632
Molekularna formulaC14H21ON3
CAS registarski broj146986-50-7
SMILESO=C([C@H]1CC[C@@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2
InChI1/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1
Osobine1
Dipolni moment
PubChem: 448042
Rizičnost
NFPA 704
 
 
 
 
1 Gdje god je moguće korištene su SI jedinice. Ako nije drugačije naznačeno, dati podaci vrijede pri standardnim uslovima.

Y-27632 je biohemijski alat koji se koristi u proučavanju signalnih puteva rho-vezane protein kinaze (ROCK).[1] Y-27632 selektivno inhibira p160ROCK, iako inhibira druge proteinske kinaze kao što su PKC u većim koncentracijama.[2]

Proučavan je zbog njegovih efekata na endotelne ćelije (CEC) [3] i srčane matične ćelije (CSC).[4]

Reference

  1. ^ Uehata, Masayoshi (1999). "Y-27632. Selective probe of ROCK/Rho-kinase". Jikken Igaku. 17 (7): 850–855.
  2. ^ Uehata, M; Ishizaki, T; Satoh, H; Ono, T; Kawahara, T; Morishita, T; Tamakawa, H; Yamagami, K; et al. (1997). "Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension". Nature. 389 (6654): 990–4. doi:10.1038/40187. PMID 9353125.
  3. ^ Peh, Gary S. L.; Adnan, Khadijah; George, Benjamin L.; Ang, Heng-Pei; Seah, Xin-Yi; Tan, Donald T.; Mehta, Jodhbir S. (16. 3. 2015). "The effects of Rho-associated kinase inhibitor Y-27632 on primary human corneal endothelial cells propagated using a dual media approach". Scientific Reports. 5. doi:10.1038/srep09167. ISSN 2045-2322. PMC 4387913. PMID 25823914.
  4. ^ Kan, Lijuan; Smith, Aubrie; Chen, Miao; Ledford, Benjamin T.; Fan, Huimin; Liu, Zhongmin; He, Jia-Qiang (8. 12. 2015). "Rho-Associated Kinase Inhibitor (Y-27632) Attenuates Doxorubicin-Induced Apoptosis of Human Cardiac Stem Cells". PLOS ONE. 10 (12): e0144513. doi:10.1371/journal.pone.0144513. ISSN 1932-6203. PMC 4672899. PMID 26645568.