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THOC2
Identifikatori
Aliasi	THOC2
Vanjski ID-jevi	OMIM: 300395 MGI: 2442413 HomoloGene: 69669 GeneCards: THOC2
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	123,733,056 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	41,009,551 bp
Obrazac RNK ekspresije
	; ;
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • vezivanje sa RNK; • mRNA binding;
Ćelijska komponenta	• THO complex; • nuclear speck; • THO complex part of transcription export complex; • transcription export complex; • jedro; • nukleoplazma;
Biološki proces	• poly(A)+ mRNA export from nucleus; • mRNA processing; • mRNA transport; • neuron development; • viral mRNA export from host cell nucleus; • Prerada RNK; • generation of neurons; • RNA export from nucleus; • mRNA export from nucleus; • mRNA 3'-end processing; • GO:0000767 cell morphogenesis; • blastocyst development; • Regulacija ekspresije gena; • regulation of mRNA export from nucleus; • negative regulation of neuron projection development; • stem cell division;
	Izvori:Amigo / QuickGO
Ortolozi
	57187
	331401
	ENSG00000125676
	ENSMUSG00000037475
	Q8NI27
	B1AZI6
	NM_001081550; NM_020449
	NM_001033422
	NP_001075019
	NP_001028594
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Podjedinica THO-kompleksa jest protein koji je kod ljudi kodiran genom THOC2.^[5]^[6]

THO2 je dio kompleksa TREX (transkripcija /eksport), koji uključuje TEX1 (MIM 606929), HPR1 (MIM 606930), ALY (MIM 604171) i UAP56 (MIM 606390) (prema OMIM-u).^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125676 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037475 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (maj 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. doi:10.1038/nature746. PMID 11979277.
^ ^a ^b "Entrez Gene: THOC2 THO complex 2".

Dopunska literatura

Coffey AJ; Brooksbank RA; Brandau O; et al. (1998). "Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene". Nat. Genet. 20 (2): 129–35. doi:10.1038/2424. PMID 9771704.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA; Jedrychowski M; Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Masuda S; Das R; Cheng H; et al. (2005). "Recruitment of the human TREX complex to mRNA during splicing". Genes Dev. 19 (13): 1512–7. doi:10.1101/gad.1302205. PMC 1172058. PMID 15998806.
Kimura K; Wakamatsu A; Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Beausoleil SA; Villén J; Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV; Blagoev B; Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125676 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037475 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11979277-5] Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E (maj 2002). "TREX is a conserved complex coupling transcription with messenger RNA export". Nature. 417 (6886): 304–8. doi:10.1038/nature746. PMID 11979277.

[entrez-6] "Entrez Gene: THOC2 THO complex 2".

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