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GNL3L
Identifikatori
Aliasi	GNL3L
Vanjski ID-jevi	OMIM: 300873 MGI: 2448557 HomoloGene: 134538 GeneCards: GNL3L
Lokacija gena (čovjek)
Hrom.	Hromosom X
Kraj	54,621,521 bp
Lokacija gena (miš)
Hrom.	Hromosom X (miš)
Kraj	149,800,318 bp
Ontologija gena
Molekularna funkcija	• GO:0001948, GO:0016582 vezivanje za proteine; • nucleotide binding; • GTP binding; • vezivanje sa RNK; • GO:0006184 GTPase activity;
Ćelijska komponenta	• jedro; • telomerase holoenzyme complex; • membrana; • Jedarce; • citosol;
Biološki proces	• regulation of protein stability; • negative regulation of telomere maintenance via telomerase; • positive regulation of protein homodimerization activity; • negative regulation of protein sumoylation; • positive regulation of protein localization to chromosome, telomeric region; • negative regulation of protein ubiquitination; • negative regulation of protein binding; • ribosome biogenesis;
	Izvori:Amigo / QuickGO
Ortolozi
	54552
	237107
	ENSG00000130119
	ENSMUSG00000025266
	Q9NVN8
	Q6PGG6
	NM_001184819; NM_019067
	NM_001168600; NM_198110
	NP_001171748; NP_061940
	NP_001162071; NP_932778
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

G jedarcetov protein 3-liki je protein koji je kod ljudi kodiran genom GNL3L.^[5]

Funkcija

Protein koji kodira ovaj gen jedarcetova GTPaza je neophodan za preradu ribosomske prerRNK i proliferaciju ćelija. Za ovaj gen pronađene su dvije varijante transkripta koje kodiraju isti protein.

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130119 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025266 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: G protein nucleolar 3 like". Pristupljeno 23. 10. 2017.

Dopunska literatura

Du X, Rao MR, Chen XQ, Wu W, Mahalingam S, Balasundaram D (2006). "The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA". Mol. Biol. Cell. 17 (1): 460–74. doi:10.1091/mbc.E05-09-0848. PMC 1345682. PMID 16251348.
Rao MR, Kumari G, Balasundaram D, Sankaranarayanan R, Mahalingam S (2006). "A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L". J. Mol. Biol. 364 (4): 637–54. doi:10.1016/j.jmb.2006.09.007. PMID 17034816.
Oktar PA, Yildirim S, Balci D, Can A (2011). "Continual expression throughout the cell cycle and downregulation upon adipogenic differentiation makes nucleostemin a vital human MSC proliferation marker". Stem Cell Rev. 7 (2): 413–24. doi:10.1007/s12015-010-9201-y. PMID 21063916.
Meng L, Hsu JK, Tsai RY (2011). "GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest". Oncogene. 30 (14): 1716–26. doi:10.1038/onc.2010.550. PMC 3072457. PMID 21132010.
Lin T, Meng L, Lin TC, Wu LJ, Pederson T, Tsai RY (2014). "Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively". J. Cell Sci. 127 (Pt 10): 2302–12. doi:10.1242/jcs.143842. PMC 6519424. PMID 24610951.
Thoompumkal IJ, Subba Rao MR, Kumaraswamy A, Krishnan R, Mahalingam S (2015). "GNL3L Is a Nucleo-Cytoplasmic Shuttling Protein: Role in Cell Cycle Regulation". PLoS ONE. 10 (8): e0135845. doi:10.1371/journal.pone.0135845. PMC 4537249. PMID 26274615.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000130119 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025266 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: G protein nucleolar 3 like". Pristupljeno 23. 10. 2017.

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