Murphy played college football at the University of Idaho in Moscow. One of the top pass-catchers in Idaho history, he nabbed 140 receptions during his Vandal career and gained 2,267 yards through the air. Murphy's career receptions rank seventh in Idaho history, while his yards rank fourth and his 17 career receiving touchdowns are tied for fifth. His best year was as a senior in 1992, when he was chosen first-team All-American by three publications, earned first-team All-Big Sky honors and Idaho Most Valuable Offensive Player honors. That season, he was second in Division I-AA with 68 grabs for 1,156 yards and nine touchdowns.
Murphy signed with the St. Louis Rams of the NFL in 2001, where he went on to play in the Super Bowl. He caught a pass during the drive of the game tying touchdown pass from Kurt Warner in a 20–17 loss in Super Bowl XXXVI
Kansas City Chiefs
Murphy signed with the Kansas City Chiefs on December 17, 2002. He was inactive for one game before being released on December 27.
He went undrafted in the 2006 CFL Dispersal Draft after the suspension of the Renegades' franchise, but signed with the Saskatchewan Roughriders in September 2006. He culminated his career as a member of the Riders' Grey Cup winning team in 2007.
Retirement
On November 28, 2007, it was announced that Murphy had retired from professional football. Murphy is the only player ever to play in the regular seasons of the CFL, NFL, XFL and NFL Europe, as well as the only player to suit up for the Super Bowl, Grey Cup and World Bowl championship games.
Murphy is currently the co-owner of Performance Compound in Tampa, Florida, and was married in November 2014.