According to Knight's wife Silvina, in a statement given to entertainment news website TheWrap, he had a bone marrow transplant for advanced non-Hodgkin's lymphoma in 2003.[2] However, intense cancer treatment including radiation left him, in the words of his wife, "in physical and emotional pain." [citation needed] On October 26, 2011 Wyatt Knight's body was discovered in a remote area on the island of Maui, Hawaii. Knight was a resident of Los Angeles, California but had recently been staying at a house on Maui.
According to the Associated Press, autopsy results indicated Knight died of a self-inflicted gunshot wound.[3][4] In addition to his wife, Knight was survived by two children from a previous marriage.[2][4]