Wu Xi started his football career with Hebei Tiangong in 2008 when the club was formed and joined the third tier.[1] While the club only played one season in the division, Wu's development particularly with the Chinese national youth teams was impressive enough for top tier side Shanghai Shenhua to be interested in his services, signing for the club on 17 November 2009.[2] At the start of the 2010 season, Wu would make his debut for the club on 3 April 2010 in a 2-1 win against Nanchang Bayi.[3] He scored his first goal for the club on 17 April 2010 in a 2-0 win against Tianjin Teda.[4]
On 28 February 2021, the parent company of Jiangsu Suning, Suning Holdings Group announced that operations were going to cease immediately due to financial difficulties.[9] On 11 March 2021, Wu returned joined his former club Shenhua on a free transfer.[10] On 16 June 2022, Wu would reach 100 Chinese Super League appearances for Shenhua in a 3-1 victory over Hebei.[11]
On 24 December 2014, Wu was named in China's squad for the 2015 AFC Asian Cup in Australia.[14] In the team's second group match, he scored the equalizing goal as China won 2-1 against Uzbekistan to qualify for the knockout stage.[15]
^"中国男足亚洲杯集训名单出炉 唯一新面孔是个门将" [Chinese men's football team's Asian Cup roster released, the only new face is a goalkeeper] (in Chinese). China Youth Net. 12 December 2023. Retrieved 15 January 2024.