Neikirk began his career in 1959, as a part-time sports reporter for the Lexington Herald.[2] He would join the Associated Press in 1961, working first in Louisville, Kentucky, then Lexington, and then in Frankfort as state capital correspondent. He would then move to AP's Baton Rouge, Louisiana, bureau in 1966 to cover civil rights and regional issues.[1][3] Neikirk was transferred to the AP Washington bureau in 1969 to cover U.S. economic policy.[4] Neikirk joined the Chicago Tribune Washington bureau in 1974 to cover U.S. and international economics, serving two stints as White House correspondent. He returned to Chicago in 1988, to serve as associate managing editor for financial news.[4] Neikirk was the Chief Washington correspondent for the Chicago Tribune from 1998 to 2008.
Neikirk appeared frequently on CNN, C-SPAN, and other nationally televised public affairs programs.[5] He wrote nationally syndicated column on economics for the Chicago Tribune, 1980–1994.[4] and served as news editor of the Chicago Tribune Washington bureau, from 1983 to 1988. He retired from the Chicago Tribune in 2008.
Garfield Schwartz, Gail; Neikirk, William (1983). The Work Revolution: How High-Tech Is Sweeping Away Old Jobs and Industries and Creating New Ones in New Places. New York: Rawson Associates. ISBN9780892562510. OCLC1029389109.
Neikirk, William (1987). Volcker: A Portrait of the Money Man. New York: Congdon & Weed. ISBN9780865531789. OCLC17233251.
Neikirk, William (2015). The Copperhead Club. Arlington, Virginia: William Neikirk. ISBN9780996962407.