After graduating from Yale, he worked with his father and brother in the lumber business. In 1870 he helped establish the Portville Tanning Company, serving as its manager. He was also a stockholder and president of the Chicago Lumbering Company and was a director of several other companies in Manistique, Michigan. After a visit to the Pacific Coast in 1900, he invested heavily in timber in the region, and served as president of the Lagoon Lumber Company, the Rogue River Timber Company, the Wheeler Timber Company, and the Manistique Lumber Company. He was also vice-president of the First National Bank of Olean, an incorporator and director of the Commonwealth Trust Company of Buffalo, and president of the Acme Milling Company of Olean.[1]
In 1874, Wheeler married Allie E. Mersereau. Their children were William M., John Egbert, Eleanor Knox, and Laurence Raymond. He was an elder of the Portville Presbyterian church, and served as trustee and president of the Western New York Society for the Protection of Homeless and Dependent Children.[1]
Wheeler died at home on April 28, 1911, from heart disease. He was buried in Chestnut Hill Cemetery.[8]