Twins Leila (Ashley) and Charli (Mary-Kate) Hunter[2] go to Rome to participate in a Summer Intern Program along with four others: Paolo, Nobu, Dari, and Heidi. After beginning the intern program, the sisters are soon fired due to careless mishaps.[3] They soon meet Derek Hammond, who re-hires them. They spend the day at Hammond’s house, where Leila meets bad boy Ryan, who happens to be Derek’s nephew. Leila and Ryan develop a liking for each other. Back at work, the girls are grasping more the concept of being responsible. They become great friends with the other interns. Charli and Paolo develop feelings for each other.
When attempting to deliver some designs for a shoot, Mr. Tortoni sabotages them by stealing the dresses. Leila, with Ryan’s help, captures pictures of the incident and delivers the pictures to Derek. Everyone helps to make new dresses, using Charlie’s designs, before the big day. Paolo phones his friend & ends up abducting everyone, especially Leila & Tortoni. In the end, the photoshoot goes well and Tortoni re-hires the interns. Derek arrives with the police to arrest Mr. Tortoni, and it is discovered that Tortoni was always jealous for having everything, the money, and the girl (Jamie).
The movie closes with Jamie and Derek and Charli and Paolo kissing at the Mamma Mia pizza party. Ryan tries to kiss Leila, but she tells him she’s good with just a hug. Derek decides to take all the interns to New York with him.