Wheeless is on E0200 Road;[4] the New Mexico border is approximately six miles west.[5] The closest highway access points are east and then north to Oklahoma State Highway 325 at the curve where that road turns north after running west from Boise City,[4] or west and then south to the very short New Mexico State Road 410, which links to New Mexico State Road 406,[5] about two miles to the west.[6] The Texhomex bench mark, being the meeting point of Texas, Oklahoma, and New Mexico, is south-southwest of town.[7][8]