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WNT7A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UZQ
Identifiers
Aliases	WNT7A, Wnt family member 7A, Wnt-7a
External IDs	OMIM: 601570; MGI: 98961; HomoloGene: 20969; GeneCards: WNT7A; OMA:WNT7A - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	13,880,071 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	91,388,345 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; prefrontal cortex; ; gonad; ; right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; amygdala; ; right lung; ; Brodmann area 9;
	Top expressed in
	surface ectoderm; ; set of lens fibers; ; corneal epithelium; ; epithelium of lens; ; paramesonephric duct; ; corneal endothelium; ; epithelium of vagina; ; medial ganglionic eminence; ; ventricular zone; ; Rostral migratory stream;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	receptor ligand activity; cytokine activity; frizzled binding; protein binding; signaling receptor binding;
Cellular component	endocytic vesicle membrane; endoplasmic reticulum lumen; plasma membrane; extracellular fluid; extracellular region; cell surface; Golgi lumen; extracellular exosome; presynapse; synapse;
Biological process	positive regulation of synapse assembly; cellular response to transforming growth factor beta stimulus; excitatory synapse assembly; roof of mouth development; non-canonical Wnt signaling pathway; cell fate commitment; response to estradiol; positive regulation of epithelial cell proliferation involved in wound healing; chondrocyte differentiation; axonogenesis; somatic stem cell population maintenance; uterus morphogenesis; stem cell development; positive regulation of canonical Wnt signaling pathway; negative regulation of neurogenesis; synapse organization; somatic stem cell division; embryonic digit morphogenesis; positive regulation of protein localization to synapse; embryonic axis specification; sex differentiation; negative regulation of apoptotic process; positive regulation of JNK cascade; wound healing; Wnt signaling pathway involved in wound healing, spreading of epidermal cells; response to estrogen; limb development; positive regulation of endothelial cell migration; positive regulation of transcription, DNA-templated; multicellular organism development; regulation of axonogenesis; dendritic spine morphogenesis; synaptic vesicle recycling; uterus development; regulation of axon diameter; skeletal muscle satellite cell activation; positive regulation of gene expression; cartilage development; regulation of cell population proliferation; embryonic limb morphogenesis; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; angiogenesis; oviduct development; establishment of cell polarity; central nervous system vasculogenesis; positive regulation of excitatory postsynaptic potential; positive regulation of cell population proliferation; canonical Wnt signaling pathway; synapse assembly; positive regulation of excitatory synapse assembly; dorsal/ventral pattern formation; cell proliferation in forebrain; embryonic forelimb morphogenesis; neurotransmitter secretion; cartilage condensation; lens fiber cell development; cerebellar granule cell differentiation; positive regulation of transcription by RNA polymerase II; embryonic hindlimb morphogenesis; Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7476
	22421
	ENSG00000154764
	ENSMUSG00000030093
	O00755
	P24383
	NM_004625
	NM_009527; NM_001363757
	NP_004616
	NP_033553; NP_001350686
	Wikidata
View/Edit Human	View/Edit Mouse

Protein Wnt-7a is a protein that in humans is encoded by the WNT7A gene.^[5]^[6]^[7]

Function

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% amino acid identity to the mouse Wnt7A protein. This gene not only guides the development of the anterior-posterior axis in the female reproductive tract but also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. It is also responsive to changes in the levels of sex steroid hormone in the female reproductive tract. Decreased expression of this gene in human uterine leiomyoma is found to be inversely associated with the expression of estrogen receptor alpha.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154764 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030093 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ikegawa S, Kumano Y, Okui K, Fujiwara T, Takahashi E, Nakamura Y (Dec 1996). "Isolation, characterization and chromosomal assignment of the human WNT7A gene". Cytogenet Cell Genet. 74 (1–2): 149–52. doi:10.1159/000134404. PMID 8893824.
^ Bui TD, Lako M, Lejeune S, Curtis AR, Strachan T, Lindsay S, Harris AL (Jun 1997). "Isolation of a full-length human WNT7A gene implicated in limb development and cell transformation, and mapping to chromosome 3p25". Gene. 189 (1): 25–9. doi:10.1016/S0378-1119(96)00808-6. PMID 9161407.
^ ^a ^b "Entrez Gene: WNT7A wingless-type MMTV integration site family, member 7A".