Nguyen was born in South Vietnam and moved to Canada in 1984 just nine years after the Fall of Saigon which ended the Vietnam War. He holds a Bachelor of Applied Science in electrical engineering from the University of Toronto and a Masters of Divinity from St. Augustine's Seminary in Toronto. He was ordained a priest on 9 May 1998. He then did further studies in Rome, where he received a licentiate in canon law from the Angelicum. From September 2009 to his consecration as bishop, he served as Chancellor and Moderator of the Curia of the Archdiocese of Toronto.[2]
Nguyen is Canada's first Bishop of Asian descent. He is currently the third youngest Bishop in Canada.