Santamaria got her start in the industry working as an assistant. She was a writer's assistant to John May and Suzanne Bolch on Our Hero (CBC) as well as a production assistant and production secretary. She was assistant to Director William Phillips on the 2003 film Foolproof starring Ryan Reynolds.
How to Die Alone
Santamaria was an executive producer, writer and co-showrunner alongside show creator Natasha Rothwell on the first season of How to Die Alone.[4] Rothwell plays Melissa, a neurotic fat Black woman who has never been in love, but after a brush with death she refuses to settle for anything less than the life she wants. How to Die Alone is produced by ABC Signature and Onyx Collective.
It was the first television show under Santamaria's Production banner Welcome Stranger[5] and Rothwell's production banner Big Hattie Productions.[6]
She was a writer on the Apple TV+ female-driven anthology series, Roar, based on a book of short stories by Cecelia Ahern.[8] She wrote Episode 7 "The Woman Who Returned Her Husband" starring Meera Syal, where she returns her husband to a superstore to explore new relationships and what she's been missing in her life.[9]
PEN15
She was an executive producer on Hulu's critically acclaimed second season of PEN15. The series was created by stars Maya Erskine and Anna Konkle and Sam Zvibleman. In Season Two she wrote Episode 4 "Three" as well as the series finale "Home." Santamaria was nominated for a 2021 Emmy Award for Outstanding Comedy Series for PEN15.[10] The show has won four awards including two Critics' Choice Awards and was nominated for a 2021 Writers Guild of America Award for Television: Comedy Series.[11][12]
Santamaria served as the co-executive producer / supervising producer between 2015 and 2016 on the Netflix series BoJack Horseman In Season 2 she wrote episode 6, "Higher Love" and in Season 3 she wrote episode 2 "The BoJack Horseman Show" and episode 10,[15] "It's You". BoJack Horseman starred Will Arnett, Amy Sedaris, Alison Brie and was nominated for awards 48 times, 3 of which were Primetime Emmys.
She co-created and executive produced How to Be Indie with Suzanne Bolch and John May. Loosely based on her life, the series starred Melinda Shankar as Indie Mehta, a role that garnered her a 2013 Canadian Screen Award for Best Performance in a Children's or Youth Program or Series for the episode "How to Be the Hero".[18] The series was nominated for various awards including the Writers Guild of Canada, the Directors Guild of Canada and Gemini Awards where in 2011 it swept wins for Best Children's or Youth Fiction Program or Series, Best Writing in a Children's or Youth Program or Series, Best Performance in a Children's or Youth Program or Series and Best Direction in a Children's or Youth Program or Series.
The series had two seasons and ran from 2009 to 2011.