VTI1A

VTI1A

Identifiers

VTI1A, MMDS3, MVti1, VTI1RP2, Vti1-rp2, vesicle transport through interaction with t-SNAREs 1A

External IDs

OMIM: 614316; MGI: 1855699; HomoloGene: 39963; GeneCards: VTI1A; OMA:VTI1A - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q25.2	Start	112,446,998 bp^[1]
Band	10q25.2	End	112,818,744 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 D2	Start	55,304,727 bp^[2]
Band	19\|19 D2	End	55,615,741 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

sural nerve

Achilles tendon

pancreatic ductal cell

buccal mucosa cell

testicle

monocyte

bone marrow cells

corpus callosum

epithelium of colon

blood

Top expressed in

Rostral migratory stream

granulocyte

superior frontal gyrus

right kidney

genital tubercle

dentate gyrus of hippocampal formation granule cell

lumbar subsegment of spinal cord

tail of embryo

medial dorsal nucleus

proximal tubule

More reference expression data

n/a

Gene ontology
Molecular function	SNAP receptor activity protein binding SNARE binding
Cellular component	integral component of membrane endosome Golgi apparatus membrane synaptic vesicle autophagosome soma SNARE complex perinuclear region of cytoplasm neuron projection terminus cytoplasmic vesicle clathrin-coated vesicle trans-Golgi network membrane ER to Golgi transport vesicle membrane cytosol Golgi membrane late endosome membrane endoplasmic reticulum membrane intracellular membrane-bounded organelle
Biological process	voluntary musculoskeletal movement autophagy retrograde transport, endosome to Golgi protein transport intracellular protein transport Golgi ribbon formation vesicle-mediated transport Golgi to vacuole transport vesicle fusion with Golgi apparatus intra-Golgi vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport protein targeting to vacuole
Sources:Amigo / QuickGO

Species

Human

Mouse


143187


53611


ENSG00000151532


ENSMUSG00000024983


Q96AJ9


O89116

RefSeq (mRNA)

NM_145206 NM_001318203 NM_001318205 NM_001365710 NM_001365711
NM_001365712 NM_001365713 NM_001365714


NM_001293685 NM_001293686 NM_016862 NM_001360431 NM_001360432

RefSeq (protein)

NP_001305132 NP_001305134 NP_660207 NP_001352639 NP_001352640
NP_001352641 NP_001352642 NP_001352643


NP_001280614 NP_001280615 NP_058558 NP_001347360 NP_001347361

Location (UCSC)

Chr 10: 112.45 – 112.82 Mb

Chr 19: 55.3 – 55.62 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Vesicle transport through interaction with t-SNAREs homolog 1A is a protein that in humans is encoded by the VTI1A gene.^[5]^[6]

The protein encoded by the VTI1A gene is a vesicular-SNARE (v-SNARE) protein which is located in the membranes of target vesicle compartments.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151532 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024983 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: vesicle transport through interaction with t-SNAREs homolog 1A (yeast)".
^ Fischer von Mollard G, Stevens TH (January 1998). "A human homolog can functionally replace the yeast vesicle-associated SNARE Vti1p in two vesicle transport pathways". J. Biol. Chem. 273 (5): 2624–30. doi:10.1074/jbc.273.5.2624. PMID 9446565.
^ "VTI1A vesicle transport through interaction with t-SNAREs 1A [Homo sapiens (Human)] - Gene - NCBI".

Further reading

Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene Variants Associated With Ischemic Stroke: The Cardiovascular Health Study". Stroke. 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Grupe A, Li Y, Rowland C, et al. (2006). "A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
Mallard F, Tang BL, Galli T, et al. (2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". J. Cell Biol. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.
Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of Gene Variants with Incident Myocardial Infarction in the Cardiovascular Health Study". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Flowerdew SE, Burgoyne RD (2009). "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels". Biochem. J. 418 (3): 529–40. doi:10.1042/BJ20081736. PMC 2650881. PMID 19138172.
Tai G, Lu L, Wang TL, et al. (2004). "Participation of the Syntaxin 5/Ykt6/GS28/GS15 SNARE Complex in Transport from the Early/Recycling Endosome to the Trans-Golgi Network". Mol. Biol. Cell. 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMC 515336. PMID 15215310.
Antonin W, Holroyd C, Fasshauer D, et al. (2000). "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function". EMBO J. 19 (23): 6453–64. doi:10.1093/emboj/19.23.6453. PMC 305878. PMID 11101518.

v t e PDB gallery
2nps: Crystal Structure of the Early Endosomal SNARE Complex 1vcs: Solution Structure of RSGI RUH-009, an N-Terminal Domain of Vti1a [Mus musculus]

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