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VPS4B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WR0, 1XWI, 2CPT, 2JQH, 2JQK, 4U7Y
Identifiers
Aliases	VPS4B, SKD1, SKD1B, VPS4-2, MIG1, vacuolar protein sorting 4 homolog B
External IDs	OMIM: 609983; MGI: 1100499; HomoloGene: 37976; GeneCards: VPS4B; OMA:VPS4B - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	63,422,483 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	106,724,458 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; amniotic fluid; ; epithelium of nasopharynx; ; secondary oocyte; ; gingival epithelium; ; mucosa of ileum; ; oral cavity; ; Achilles tendon; ; palpebral conjunctiva; ; hair follicle;
	Top expressed in
	conjunctival fornix; ; ciliary body; ; Paneth cell; ; lacrimal gland; ; hair follicle; ; primitive streak; ; iris; ; vestibular sensory epithelium; ; medullary collecting duct; ; ureter;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein homodimerization activity; ATPase activity; protein C-terminus binding; protein binding; identical protein binding; hydrolase activity; ATP binding;
Cellular component	cytoplasm; cytosol; endosome; centrosome; spindle pole; membrane; late endosome membrane; Flemming body; endosome membrane; extracellular exosome; nucleus;
Biological process	late endosomal microautophagy; regulation of centrosome duplication; protein depolymerization; viral budding via host ESCRT complex; viral life cycle; nucleus organization; cholesterol transport; negative regulation of exosomal secretion; multivesicular body assembly; negative regulation of cell death; regulation of mitotic spindle assembly; endosome organization; cell division; positive regulation of centriole elongation; endosomal transport; potassium ion transport; response to lipid; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway; protein transport; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of exosomal secretion; septum digestion after cytokinesis; mitotic metaphase plate congression; endosome to lysosome transport via multivesicular body sorting pathway; cell cycle; ESCRT III complex disassembly; macroautophagy; transport; positive regulation of viral process; vacuole organization; midbody abscission;
	Sources:Amigo / QuickGO
Orthologs
	9525
	20479
	ENSG00000119541
	ENSMUSG00000009907
	O75351
	P46467
	NM_004869
	NM_009190
	NP_004860; NP_004860.2
	NP_033216
	Wikidata
View/Edit Human	View/Edit Mouse

Vacuolar protein sorting-associated protein 4B is a protein that in humans is encoded by the VPS4B gene.^[5]^[6]

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein.

In humans, two paralogs of the yeast protein have been identified. They share a high degree of amino acid sequence similarity with each other and also with yeast Vps4 and mouse proteins. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other (VPS4A) resides on chromosome 16.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119541 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000009907 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scheuring S, Rohricht RA, Schoning-Burkhardt B, Beyer A, Muller S, Abts HF, Kohrer K (Sep 2001). "Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking". J Mol Biol. 312 (3): 469–80. doi:10.1006/jmbi.2001.4917. PMID 11563910.
^ ^a ^b "Entrez Gene: VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)".