VPREB3

VPREB3
Identifiers
AliasesVPREB3, 8HS20, N27C7-2, pre-B lymphocyte 3, V-set pre-B cell surrogate light chain 3
External IDsOMIM: 605017; MGI: 98938; HomoloGene: 7598; GeneCards: VPREB3; OMA:VPREB3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

29802

22364

Ensembl

ENSG00000128218

ENSMUSG00000000903

UniProt

Q9UKI3

n/a

RefSeq (mRNA)

NM_013378

NM_009514
NM_001358532

RefSeq (protein)

NP_037510

n/a

Location (UCSC)Chr 22: 23.75 – 23.75 MbChr 10: 75.78 – 75.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pre-B lymphocyte protein 3 is a protein that in humans is encoded by the VPREB3 gene.[5][6][7][8]

The VPREB3 gene product is the human homologue of the mouse VpreB3 (8HS20) protein, and is specifically expressed in cell lines representative of all stages of B-lymphocyte differentiation. It is also related to VPREB1 and other members of the immunoglobulin supergene family. The VPREB3 protein apparently associates with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. The precise function of VPREB3 is not known, but it may contribute to mu chain transport in pre-B cells.[6][8] In humans, besides the bone marrow and secondary lymphoid tissues such as the tonsils, the VPREB3 protein is also present in Purkinje cells of the cerebellum and in the zona glomerulosa of the adrenal.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128218 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000903 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rosnet O, Mattei MG, Delattre O, Schiff C (Apr 2000). "VPREB3: cDNA characterization and expression in human and chromosome mapping in human and mouse". Cytogenet Cell Genet. 87 (3–4): 205–8. doi:10.1159/000015468. PMID 10702669. S2CID 5914943.
  6. ^ a b c Felizola SJ, Katsu K, Ise K, Nakamura Y, Arai Y, Satoh F, Sasano H (2015). "Pre-B lymphocyte protein 3 (VPREB3) expression in the adrenal cortex: precedent for non-immunological roles in normal and neoplastic human tissues". Endocrine Pathology. [in press].
  7. ^ Rosnet O, Blanco-Betancourt C, Grivel K, Richter K, Schiff C (Mar 2004). "Binding of free immunoglobulin light chains to VpreB3 inhibits their maturation and secretion in chicken B cells". J Biol Chem. 279 (11): 10228–36. doi:10.1074/jbc.M312169-A200. PMID 14670953.
  8. ^ a b "Entrez Gene: VPREB3 pre-B lymphocyte gene 3".

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