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VAV1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9
Identifiers
Aliases	VAV1, VAV, vav guanine nucleotide exchange factor 1
External IDs	OMIM: 164875; MGI: 98923; HomoloGene: 3961; GeneCards: VAV1; OMA:VAV1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,857,366 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,635,031 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; monocyte; ; blood; ; spleen; ; bone marrow cells; ; lymph node; ; appendix; ; palpebral conjunctiva; ; epithelium of nasopharynx; ; trabecular bone;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; granulocyte; ; thymus; ; mesenteric lymph nodes; ; interventricular septum; ; spleen; ; blood; ; gastrula; ; lumbar subsegment of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; DNA-binding transcription factor activity; metal ion binding; protein binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphotyrosine residue binding;
Cellular component	cytosol; cell-cell junction; plasma membrane;
Biological process	regulation of cell size; intracellular signal transduction; Fc-gamma receptor signaling pathway involved in phagocytosis; regulation of GTPase activity; T cell costimulation; neutrophil chemotaxis; reactive oxygen species metabolic process; platelet activation; Fc-epsilon receptor signaling pathway; positive regulation of GTPase activity; T cell differentiation; vascular endothelial growth factor receptor signaling pathway; immune response; phagocytosis; positive regulation of apoptotic process; integrin-mediated signaling pathway; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; positive regulation of natural killer cell mediated cytotoxicity; T cell activation; positive regulation of cell adhesion; regulation of transcription, DNA-templated; phosphatidylinositol phosphate biosynthetic process; small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway; positive regulation of protein kinase B signaling; cytokine-mediated signaling pathway; positive regulation of Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	7409
	22324
	ENSG00000141968
	ENSMUSG00000034116
	P15498
	P27870
	NM_001258206; NM_001258207; NM_005428
	NM_001163815; NM_001163816; NM_011691
	NP_001245135; NP_001245136; NP_005419
	NP_001157287; NP_001157288; NP_035821
	Wikidata
View/Edit Human	View/Edit Mouse

Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.^[5]

Function

The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.^[6]