The hospital has its origins in the Dental Department of the Bristol Royal Infirmary which was established in 1883.[2] The first dental degree was awarded to a student in 1912.[2]
A site for a purpose-built dental hospital was selected in Lower Maudlin Street and construction started in 1935.[2] The dental hospital and school opened in 1939 and was extended in 1965, 1973, 1985 and 1995.[2] A major expansion and refurbishment was completed in 2009.[4]