In 2012, Saren joined Junglemahal Bhoomiputra and Kanya Medical Association whose aim was to provide medical facilities in remote areas to the tribals in the Bengal-Jharkhand border.[3]
On 5 May 2014, Trinamool Congress party announced that Saren would contest the upcoming general election from Jhargram constituency.[4] She was pitted against Communist Party of India (Marxist) candidate Pulin Bihari Baske.[5] In May, she was elected to the Lok Sabha and defeated Baske by a margin of 3,50,756 votes. She became the first ever woman SanthalMP of India.[2][6] She also won with the highest margin in her state.[6]
In 2014, she was the member of two standing parliamentary committees: the Standing Committee on Chemicals and Fertilizers and the Consultative Committee on Ministry of Tribal Affairs.[7]
In April 2017, Saren utilised ₹16.39 crore (US$1.9 million) from her MPLADS funds to buy ceiling fans, LED lamps and water coolers for 3,000 schools in the state.[8]
On 28 May 2018, Saren became the first person to speak in the Santali language in the Inter-Parliamentary Union.[9] She spoke about the many problems faced by various tribes in India. She was also the only woman in the Indian delegation which consisted of seven members.[9][10][11]
On 12 March 2019, the party announced that they had not renominated Saren for the next general election.[12] Partymen alleged that she did not use the MPLADS funds.[13]