Spears rushed for 192 yards and one touchdown and caught five passes for 133 yards and one touchdown in four games during his freshman season at Tulane.[4][5] He began his sophomore season as the Green Wave's starting running back and rushed 37 times for 274 yards and two touchdowns before suffering a season-ending injury in Week 3 and using a medical redshirt.[6] As a redshirt sophomore, Spears gained 863 yards and scored nine touchdowns on 129 carries.[7] He was named the American Athletic Conference Offensive Player of the Year as a redshirt junior.[8] He was ranked the 6th best college football player nationwide among the "100 Best Players of the College Football Bowl Season 2022–2023" by College Football News.[9]
Spears was drafted by the Tennessee Titans in the third round, 81st overall, of the 2023 NFL draft.[12] In Week 5, against the Colts, he scored his first professional touchdown on a 19-yard rush.[13] He finished his rookie season with 453 rushing yards and two touchdowns along with 52 catches for 385 yards and one touchdown.[14]