Trimerelysin I

Trimerelysin I
Identifiers
EC no.3.4.24.52
CAS no.151125-16-5
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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Trimerelysin I (EC 3.4.24.52, Trimeresurus metalloendopeptidase I, hemorrhagic proteinase HR1A, hemorrhagic metalloproteinase HR1A, metalloproteinase HR1A) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Cleavage of only two bonds His10-Leu and Ala14-Leu in the insulin B chain

This endopeptidase is present in the venom of the habu snake (Trimeresurus flavoviridis).

References

  1. ^ Omori-Satoh T, Sadahiro S (October 1979). "Resolution of the major hemorrhagic component of Trimeresurus flavoviridis venom into two parts". Biochimica et Biophysica Acta (BBA) - Protein Structure. 580 (2): 392–404. doi:10.1016/0005-2795(79)90151-x. PMID 518906.
  2. ^ Yamakawa Y, Omori-Satoh T (1988). "The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis)". Toxicon. 26 (2): 227–31. doi:10.1016/0041-0101(88)90178-x. PMID 3284004.
  3. ^ Takeya H, Oda K, Miyata T, Omori-Satoh T, Iwanaga S (September 1990). "The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis". The Journal of Biological Chemistry. 265 (27): 16068–73. PMID 2398046.