The Yankees invited Lane to spring training in 2018 as a non-roster player.[8] He began the year with Tampa and was promoted in May to the Trenton Thunder of the Double–AEastern League. Over 68 relief innings pitched between the two teams, Lane compiled a 2–4 record with a 3.97 ERA, striking out 82 batters.[9] He returned to Trenton to begin the 2019 season, and he also spent time during the year with the Tarpons and the Scranton/Wilkes-Barre RailRiders of the Triple–AInternational League. Over 74+2⁄3 relief innings between the three clubs, Lane went 6–2 with a 2.05 ERA, striking out 74 batters. He did not play in a game in 2020 due to the cancellation of the minor league season because of the COVID-19 pandemic.[10]
Lane spent the 2021 season with Triple-A Scranton, posting a 4-0 record and 1.99 ERA with 28 strikeouts in 22+2⁄3 innings pitched. Lane was assigned to the Scranton to begin the 2022 season. After working to a 2.08 ERA with 25 strikeouts in 21+2⁄3 innings of work, he was released by the Yankees organization on July 5, 2022.[12]
On March 30, 2023, Lane re-signed with the Dogs for the 2023 season.[14] He made 23 appearances (18 starts) for the Dogs, compiling a 6–7 record and 5.17 ERA with 96 strikeouts across 102+2⁄3 innings. Lane would become a free agent after the 2023 season.