Smith was drafted by the Kansas City Chiefs in the sixth round (196th overall) of the 2018 NFL draft.[5] He primarily played on special teams (particularly as a kick returner) during his rookie season, but also saw some playing time on defense as a cornerback. During the 2018 season, he had 33 returns for 886 yards, averaging 26.8 yards per return.[6] He was named to the NFL All-Rookie Team as a returner.[7]
Prior to the 2019 season, the Chiefs moved Smith from cornerback to running back;[8] after the preseason, however, he was moved back to cornerback.
Smith was waived by the Chiefs on September 14, 2019.[9]
Green Bay Packers
Smith was claimed off waivers by the Green Bay Packers on September 17, 2019.[10] He was waived on October 14 and re-signed to the practice squad two days later.[11][12] He was promoted to the active roster on October 29.[13] On December 2, 2019, Smith was waived by the Packers.[14]
Philadelphia Eagles
On December 4, 2019, Smith was signed to the Philadelphia Eagles practice squad.[15] He signed a reserve/future contract with the Eagles on January 6, 2020.[16] He was waived on July 26, 2020.[17]
Indianapolis Colts
On August 16, 2020, Smith signed with the Indianapolis Colts.[18] He was waived on September 5, 2020,[19] and re-signed to the team's practice squad the next day.[20] He was promoted to the active roster on September 22, 2020.[21]
Houston Texans
Smith signed with the Houston Texans on March 22, 2021.[22] During a stellar season as a core special teamer, Smith signed a one-year contract extension on December 3, 2021.[23] In Week 15, Smith had a 98-yard kick return touchdown and downed a punt inside the five-yard line in a 30–16 win over the Jacksonville Jaguars, earning American Football Conference Special Teams Player of the Week.[24] On December 11, 2022, in a game against the Dallas Cowboys, Smith intercepted the Cowboys' quarterback Dak Prescott twice marking the first and second of his career.[25]
Denver Broncos
On March 17, 2023, the Denver Broncos signed Smith to a two-year contract.[26]