Kaye then moved to Los Angeles, where he acted in many television shows, including the miniseries, Sidney Sheldon's Nothing Lasts Forever, before moving to New York to play Patrick Thornhart on ABC's One Life to Live (1995–1997). The character gained quite a bit of popularity, and it is where he would meet his real life partner, Susan Haskell. After completing a two-year stint on OLTL, Thorsten did some guest starring work for other shows, as well as starring in a few feature films.
In April 2000, Thorsten accepted the role of the dedicated physician Ian Thornhart (Patrick's older brother) on the ABC daytime soap (and the spin-off show of General Hospital), Port Charles (2000–2003). He appeared on the soap until its run ended in October 2003. Thorsten received two Daytime Emmy Award Nominations for Outstanding Lead Actor for his portrayal of Ian in 2003 and 2004.
In April 2004, Thorsten returned to New York to join the cast of the ABC soap All My Children in the role of casino owner, Zach Slater. He was nominated for two Daytime Emmy Awards in 2006 and 2009. Thorsten portrayed Slater until December 2009. He returned three times in 2010, and again in 2011 to bring Zach's storyline to a close when AMC came to an end after 41 years, in September 2011.
Thorsten Kaye has one of the lead roles in a new psychological thriller (feature-length film) titled Occupant, which was released in the U.S and Canada in October 2011 on demand in many cable/satellite markets as well as on most digital platforms, including iTunes, Amazon, Blockbuster, and PlayStation.