Thomas Culpeper (c. 1514–1541) was a courtier at Henry VIII's court, executed for adultery with Queen Catherine Howard.

Thomas Culpeper (Culpepper or Colepeper) may also refer to:

• Thomas Colepeper (died 1613) (c. 1561–1613), MP for Winchelsea and Rye
• Thomas Colepeper (Royalist) (1578–1661), MP for Tewkesbury
• Thomas Colepeper, 2nd Baron Colepeper (1635–1689), Governor of Virginia
• Thomas Colepeper (colonel) (1637–1708), English colonel
• Sir Thomas Culpeper, 3rd Baronet (1656–1723), English MP

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