It was founded in 1984 as Co-LAB by a group of five art students (Laura Brun, John DiStefano, Tami Logan, Alan Millar, and Nomi Seidman) from San Francisco State University.[2][3] It changed its name from Co-Lab to The Lab in 1985.[2][4][5]
Its original site was at 1805 and 1807 Divisadero Street; in 1995 it moved to the Redstone Building in the Mission District.[2][4] In 2018 the organization began paying fees of $25,000 to $75,000 to artists in residence.[1] In 2019, in collaboration with the Mission Economic Development Agency, it launched a campaign to purchase the Redstone building.[6][7][8]