The show was hosted by two life-size female puppets named Honey and Sis: Honey (voiced by Udana Power) is a 19-year-old willowy tall blond who fancies herself a gifted performer, while her 17-year-old red-headed sister Sis (voiced by Wendy McKenzie) is actually the talented one.[2] On each episode, Honey and Sis sang, danced and participated in comedy sketches as "The Disco of Life", a soap opera parody where they interacted with people at a disco, and "The Truth Tub" where they relaxed in a hot tub and parodied TV shows such as Laverne & Shirley and Three's Company.
Honey and Sis were designed by Hanna-Barbera animator Iwao Takamoto and their costumes created by fashion designer Bob Mackie. They were manipulated by a team of six puppeteers who would wear full-body blue leotards in front of a blue screen, so that the two characters would be chroma-keyed on a different background.
April 23: Gavin MacLeod, Anson Williams, Charo, Yogi Bear; the Elmira Star-Gazette said in advance "In the truth tub this week is Anson; his problem is that girls want him for the wrong reasons. Are any adults watching?"[5]
Although only scheduled for a five-week test run, The Hanna-Barbera Happy Hour failed in the ratings as it competed with ABC's Welcome Back, Kotter and What's Happening!! and was taken off the air, with reruns of CHiPs taking over its timeslot.