The film traces the band from their roots as a local psychedelicpunk band to an internationally renowned band that draws celebrities to its performances. Many of the interviews were filmed in the band's hometown of Oklahoma City, although Wayne Coyne is the only band member still living there. In addition to the development of the Lips' music and performance, another theme running through the movie is the effect that drugs have had on the band and their families. A notable scene in the film depicts Steven Drozd preparing to inject himself with heroin, and it is stated that paranoia over Drozd's addiction caused guitaristRonald Jones to leave the band. Drugs have also affected the lives of members of both Drozd's and Coyne's families.