Unconscious after his bachelor party, Peter De Haven (Jeffrey Lynn) is transported by his friends to the college dissecting room as a practical joke. Professor Shotesbury (Edward Everett Horton) mistakenly injects him with a serum that makes him invisible. While invisible, De Haven learns that his fiancee, Christine (Marguerite Chapman), is only marrying him for his money. He also falls in love with Shotesbury's daughter, Joan (Jane Wyman). Meanwhile, Shotesbury is committed to a sanatorium by his colleagues for his claims about invisible monkeys and men. De Haven and Joan, by this time also invisible, go to release Shotesbury from the mental hospital, which they achieve by making him invisible as well. All the while time is running out for De Haven to receive an antidote. In the end, all receive the antidote, and De Haven ends up with Joan.[3]
Writing in AllMovie, critic Hal Erickson described the film as "an agreeably daffy comedy with science-fiction undertones," having "all manner of looney complications" and "still fresh and funny after nearly six decades."[4] A review of the film in TV Guide described it as a "funny B movie" with "fine special effects [that] highlight this variation of the 'invisible man' theme," noting further that "Horton and wide-eyed Best [give] fine comic performances."[5] Critic Dennis Schwartz described the film as a "delightful screwball comedy" and "the kind of old-fashioned comedy that can cheer you up with a few laughs if you are down, or if you are in a silly mood make you feel even sillier."[6]