The Tefé River flows through the Juruá-Purus moist forests ecoregion.[3]
It forms the eastern boundary of the Tefé National Forest, created in 1989.[4]
Immediately before merging into the Amazon, it forms Lake Tefé (Portuguese: Lago Tefé). The city of Tefé is located on the banks of the lake. The Tefé River is a blackwater river.