Scott spent the entirety of 2018 with Triple–A Round Rock, appearing in 44 contests and pitching to a 5–5 record and 3.26 ERA with 52 strikeouts across 60+2⁄3 innings pitched. He elected free agency following the season on 2 November 2018.[9]
Scott was called up to the major leagues for the first time on 7 June 2019.[1] He made his major-league debut on 8 June, becoming the first South African pitcher in MLB history.[11] He pitched 2+2⁄3 innings in his debut, against the Los Angeles Angels, allowing three runs on four hits. His first strikeout was against Wilfredo Tovar.[12]
Baltimore Orioles
On 25 June 2019, Scott was claimed off waivers by the Baltimore Orioles.[13] In eight appearances for the Orioles, Scott struggled to an 18.69 ERA with 7 strikeouts in 8+2⁄3 innings of work. He was markedly better with the Triple–A Norfolk Tides, registering a 0.56 ERA with 21 strikeouts across 13 appearances.[14] On 30 October, Scott was removed from the 40-man roster and sent outright to Triple–A Norfolk.[15] He elected free agency on 4 November.[16]
Hiroshima Toyo Carp
On 1 December 2019, Scott signed a one-year contract with the Hiroshima Toyo Carp of Nippon Professional Baseball (NPB).[17][18] In 2020, Scott struggled to a 15.75 ERA in 7 games for Hiroshima.[4] Scott did not appear in a regular season game for the Carp in 2021 and became a free agent after the season.[citation needed]
On 14 September 2022, Scott was claimed off waivers by the Philadelphia Phillies.[20] In four appearances for the Triple–A Lehigh Valley IronPigs, Scott struggled to a 15.00 ERA with four strikeouts in three innings of work. He was designated for assignment on 16 December, after the Phillies signed Taijuan Walker.[21] Scott cleared waivers and was sent outright to Triple–A on 23 December;[22] however, he declined the assignment and became a free agent.[23]
Los Angeles Dodgers
On 7 January 2023, Scott signed a minor-league contract with the Los Angeles Dodgers.[24] He began the season with Triple-A Oklahoma City, allowing only two earned runs in 16+2⁄3 innings before he was called up to the majors on 22 May.[25] He pitched six innings across six games for the Dodgers, posting a 9.00 ERA before he was designated for assignment on 17 June.[26]
Boston Red Sox
On 22 June 2023, Scott was traded to the Boston Red Sox in exchange for cash considerations;[27] he was assigned to the Triple-A Worcester Red Sox.[28] On 4 July, Scott was added to Boston's active roster.[29] In four games for Boston, Scott pitched 3+2⁄3 innings and surrendered three runs (two earned) on six hits and four walks with two strikeouts. He was designated for assignment on 16 July.[30]
Oakland Athletics
On 19 July 2023, Scott was claimed off waivers by the Oakland Athletics.[31] In 8 games for Oakland, he registered a 3.38 ERA with 7 strikeouts in 8.0 innings of work. Following the season on 6 November, Scott was removed from the 40–man roster and sent outright to the Triple–A Las Vegas Aviators.[32] He elected free agency the same day.[33]
Houston Astros
On 12 December 2023, Scott signed a minor-league contract with the Houston Astros.[34] On 28 March 2024, Scott had his contract selected after making Houston's Opening Day roster.[35] Scott earned his first major league win on 2 May 2024 when he tossed 1+1⁄3 scoreless innings versus the Cleveland Guardians to support an 8–2 final.[36] The Astros placed Scott on the 15-day IL on 21 September 2024 due to thoracic spine strain. Through the point of the roster move, Scott had made the third-most appearances for the Astros and had produced a 2.23 ERA, 25.2% strikeout rate, and 3.5% barrel rate over his 68+2⁄3 innings. He did struggle with walks, however, at 12.4%.[37]