TAF4B
Protein-coding gene in the species Homo sapiens
Transcription initiation factor TFIID subunit 4B is a protein that in humans is encoded by the TAF4B gene .[ 5] [ 6] [ 7]
Function
TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM 600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in the initiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM][ 7]
Interactions
TAF4B has been shown to interact with RELA .[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000141384 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054321 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Dikstein R, Zhou S, Tjian R (Nov 1996). "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130" . Cell . 87 (1): 137– 46. doi :10.1016/S0092-8674(00)81330-6 PMID 8858156 . S2CID 10194253 . ^ Yamit-Hezi A, Nir S, Wolstein O, Dikstein R (Jul 2000). "Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes" . J. Biol. Chem . 275 (24): 18180– 7. doi :10.1074/jbc.275.24.18180 PMID 10849440 . ^ a b "Entrez Gene: TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa" .^ Yamit-Hezi A, Dikstein R (Sep 1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB" . EMBO J . 17 (17): 5161– 9. doi :10.1093/emboj/17.17.5161 . PMC 1170844 PMID 9724652 .
Further reading
Liu WL, Coleman RA, Grob P, King DS, Florens L, Washburn MP, Geles KG, Yang JL, Ramey V, Nogales E, Tjian R (2008). "Structural changes in TAF4b-TFIID correlate with promoter selectivity" . Mol. Cell . 29 (1): 81– 91. doi :10.1016/j.molcel.2007.11.003 . PMC 2486835 PMID 18206971 . Wu Y, Lu Y, Hu Y, Li R (2005). "Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line". J. Cell. Biochem . 96 (4): 751– 9. doi :10.1002/jcb.20577 . PMID 16088961 . S2CID 23658728 . Shao H, Revach M, Moshonov S, Tzuman Y, Gazit K, Albeck S, Unger T, Dikstein R (2005). "Core promoter binding by histone-like TAF complexes" . Mol. Cell. Biol . 25 (1): 206– 19. doi :10.1128/MCB.25.1.206-219.2005 . PMC 538770 PMID 15601843 . Rashevsky-Finkel A, Silkov A, Dikstein R (2001). "A composite nuclear export signal in the TBP-associated factor TAFII105" . J. Biol. Chem . 276 (48): 44963– 9. doi :10.1074/jbc.M106112200 PMID 11567023 . Wolstein O, Silkov A, Revach M, Dikstein R (2000). "Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription" . J. Biol. Chem . 275 (22): 16459– 65. doi :10.1074/jbc.275.22.16459 PMID 10828057 . Yamit-Hezi A, Dikstein R (1998). "TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB" . EMBO J . 17 (17): 5161– 9. doi :10.1093/emboj/17.17.5161 . PMC 1170844 PMID 9724652 .
