After Casimir's death in 1527, Susanna married Otto Henry, Count Palatine of Neuburg, on 16 October 1529. This second marriage produced no children.
Susanna died on 23 April 1543 in Neuburg an der Donau.[1] She was 41 years old. She never became Electress Palatine, since she died before her second husband acquired the electoral dignity.