Streptothricins are a group of antibiotics in the aminoglycoside class.[1] The first antibiotic in the group was isolated from Streptomyces lavendulae in 1942.[2] It was later determined to be a mixture of closely-related compounds, and is now known as nourseothricin. Although initial interest was positive because it appeared to be the first broad-spectrum antibiotic, meaning it was effective against both Gram-positive and Gram-negative bacteria, it never found clinical use due to toxicity.[3] However, because of the increasing need for new antibiotics due to resistance to existing antibiotics, there is a current interest in developing new drugs based on the chemical scaffold of the streptothricins.[1][4][5]
^Waksman, S. A. & Woodruff, H. B. (1942). "Streptothricin, a new selective bacteriostatic and bactericidal agent, particularly active against Gram-negative bacteria". Proc. Soc. Exp. Biol. Med. 49 (2): 207–210. doi:10.3181/00379727-49-13515.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^STANLEY AR (1946). "Proceedings of Local Branches of the Society of American Bacteriologists". Journal of Bacteriology. 52 (3): 399–404. doi:10.1128/JB.52.3.399-404.1946. PMID21065179.
