Tanksley joined the faculty at Cornell in 1985 as an associate professor of plant breeding, and became full professor in 1994. He led the development of the first molecular maps of tomato [1] and rice.[2] In 1993, Tanksley was the head of a Cornell research group that isolated and subsequently cloned a disease-resistance gene in tomato plants. The research is believed to be the first successful DNA map-based cloning in a major crop plant.[3]
Much of Tanksley's work focused on identifying alleles from wild relatives of crops that could be useful in improving cultivated varieties, for example fruit size and shape in tomato,[4] using the technology Marker-assisted selection (MAS). He led work developing the advanced backcrossQuantitative Trait Loci (QTL) method, facilitating the introgression of new alleles into cultivated breeding lines.[5] His team also spearheaded using genetic markers in comparative mapping among Solanaceae species[6] and others.[7][8]
In 2006, Tanksley co-founded Nature Source Genetics, a company based in Ithaca, NY, conceived to work on creating new computer algorithms to improve the efficiency of using natural genetic diversity in crop improvement. In 2016, Nature Source Genetics merged with the In Vitro division of Agromod, a Mexican company specializing in plant propagation, to form Nature Source Improved Plants, LLC,[9] a US-based company dedicated to the genetic improvement, propagation, and sales of high performing plant materials.[10] The company has one division in Ithaca, NY and one in Tapachula, Mexico.
^Tanksley, S., M. Causse, T. Fulton, N. Ahn, Z. Wang, K. Wu, J. Xiao, P. Ronald, Z. Yu, G. Second, and S. McCouch (1992). "A high density molecular map of the rice genome". Rice Genetics Newsletter. 9.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Fisher, Lawrence M. (1993). "Tomato Gene That Resists Disease Is Cloned". The New York Times. p. A25.
^Tanksley, S.D. and J.C. Nelson (1996). "Advanced backcross QTL analysis: a method for the simultaneous discovery and transfer of valuable QTLs from unadapted germplasm into elite breeding lines". Theor. Appl. Genet. 92 (2): 191–203. doi:10.1007/BF00223376. PMID24166168. S2CID24001863.