South Carolina Highway 45
Route information
Maintained by SCDOT
Length	76.060 mi[1][2][3] (122.407 km)
Existed	1922[citation needed]–present
Major junctions
South end	US 17 in McClellanville
Major intersections	US 17 Alt. in Jamestown US 52 in St. Stephen
North end	US 15 / US 176 in Wells
Location
Country	United States
State	South Carolina
Counties	Charleston, Berkeley, Orangeburg
Highway system
South Carolina State Highway System Interstate US State Scenic
← SC 41 → SC 46

South Carolina Highway 45 (SC 45) is a 76.060-mile (122.407 km) primary state highway in the U.S. state of South Carolina. It serves as the main thoroughfare in northern Berkeley County.^[4]

This section is empty. You can help by adding to it. (September 2013)

Established as an original state highway in 1922, it traversed from SC 41 in St. Stephen to SC 31 in St. Matthews. Around 1926, SC 45 was truncated 4 miles (6.4 km) west of St. Stephen along a new alignment of SC 41 (current U.S. Route 52 or US 52). By 1931, SC 45 was extended west on new primary routing to SC 24 in Pelion. In 1937 or 1938, SC 45 was extended along US 52 east to St. Stephen, then east on new primary routing to SC 179 (current US 17 Alternate or US 17 Alt.) near Jamestown; this was SC 45's longest routing at over 105 miles (169 km).^{[citation needed]}

In 1939, SC 45 was rerouted onto new primary routing west of Eutawville to its current northern terminus with US 15/SC 31 in Wells. The section of road from Eutawville west to Swansea became part of SC 6; Swansea to Pelion became SC 69.^{[citation needed]}

In 1942, both Santee Reservoir (Lake Marion) and Pinopolis Reservoir (Lake Moultrie) begin to be filled causing SC 45 to be altered. SC 45 was rerouted southeast along SC 6 to Cross then north around Lake Moultrie to meet back with the original SC 45 east of Eadytown; the old alignment became secondary roads Fredcon Road (S-38-137) and Edgewater Road (S-8-31) with the rest under Lake Marion. In 1948, SC 45 was truncated west again of St. Stephen onto US 52; however a year later it was extended back to SC 179, near Jamestown. In 1950, SC 45 was rerouted west of Cross onto new primary routing and bridge over the Diversion Canal; the old alignment that hugged Lake Moultrie's shoreline became secondary road Ranger Drive (S-8-132). Around 1952, SC 45 was taken off a 4-mile (6.4 km) concurrency with US 52 and given a new routing between Pineville and St. Stephen; this left behind Colonel Manham Drive (S-8-6). Also, SC 45 was extended east to Jamestown, in concurrency with US 17 Alt., then continue southeast, replacing SC 173, to its current southern terminus with US 17/US 701, in McClellanville. In the late 1990s, a one-block concurrency was eliminated in St. Stephen.^{[5][6][7][8][9][10]}

County	Location	mi[4]	km	Destinations	Notes
Charleston	McClellanville	0.000	0.000	US 17 / South Pinckney Street south – Georgetown, Charleston	Southern terminus; South Pinckney Street continues past terminus.
Berkeley	Jamestown	20.699	33.312	US 17 Alt. north / SC 41 – Georgetown, Charleston	Southern end of US 17 Alt. concurrency
	​	24.390	39.252	US 17 Alt. south – Moncks Corner	Northern end of SC 17 Alt. concurrency
	St. Stephen	38.030	61.203	US 52 (Byrnes Drive) – Kingstree, Moncks Corner
	​	56.380	90.735	SC 6 east – Moncks Corner	Southern end of SC 6 concurrency
Orangeburg	Eutawville	67.370	108.422	SC 6 west – Santee	Northern end of SC 6 concurrency
		68.060	109.532	SC 453 south / SC 453 Truck begins (Eutaw Road) – Holly Hill	Southern end of SC 453 Truck concurrency; northern terminus of SC 453 and SC 453 Truck
	​	72.460	116.613	SC 310 / SC 453 Truck south (Camden Road) – Vance, Holly Hill	Northern end of SC 453 Truck concurrency; roundabout
	Wells	76.060	122.407	US 15 (Bass Drive) / US 176 (Old State Road) – Santee, Camden, St. George, Holly Hill	Northern terminus; to Santee State Park
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• U.S. roads portal

• Media related to South Carolina Highway 45 at Wikimedia Commons
• Mapmikey's South Carolina Highways Page: SC 45