Sorin Draghici

Sorin Drăghici
CitizenshipUnited States
Alma materUniversity of St Andrews, UK
Scientific career
FieldsComputer Science, Bioinformatics, Computational biology, Machine learning, Neural networks, and Biomedical Informatics
InstitutionsNational Science Foundation, Wayne State University

Sorin Drăghici is a Romanian-American computer scientist and a program director in the Division of Information and Intelligent Systems (IIS) of the Directorate for Computer and Information Science and Engineering (CISE) at the National Science Foundation (NSF). Previous positions include: Associate Dean for Entrepreneurship and Innovation of Wayne State University's College of Engineering, the Director of the Bioinformatics and Biostatistics Core at Karmanos Cancer Institute, and the Director of the James and Patricia Anderson Engineering Ventures Institute.[1][2] Draghici was elected a Fellow of the Institute of Electrical and Electronics Engineers (IEEE) in 2022, for contributions to the analysis of high-throughput genomics and proteomics data.[3] He has also been elected a Fellow of the Asia-Pacific Artificial Intelligence Association (AAIA).

Career

Draghici is a program director in the Directorate for Computer and Information Science and Engineering (CISE) at the National Science Foundation (NSF). At NSF he is responsible for programs in AI and computational biology such as Accelerated Computing-Enabled Scientific Discovery, Molecular Foundations of Biotechnology, Safe Learning-Enabled Systems, Formal Methods in the Field, Global Centers, and others.

He is also a Professor in the Department of Computer Science, College of Engineering and Obstetrics and Gynecology in the School of Medicine at Wayne State University. Draghici is also the founder and CEO of AdvaitaBio.[4]

Research

His research area is computational biology and bioinformatics, in particular GO analysis,[5][6] pathway analysis,[7][8][9][10][11] meta-analysis,[12][13][14][15][16][17] and drug repurposing.[18][19] His research has been supported by the National Science Foundation,[20] National Health Institutes[21][22][23][24][25][26] and others. He has published over 190 scholarly papers[27][28] and two technical books: Statistics and Data Analysis for Microarrays Using R and Bioconductor[29] and Data Analysis Tools for DNA Microarrays.[30]

He is an editor for IEEE/ACM Transactions on Computational Biology and Bioinformatics,[31] Current Protocols in Bioinformatics,[32] Journal of Biomedicine and Biotechnology,[33] and a senior editor of the Discoveries Journal.[34]

References

  1. ^ "Anderson Institute - Entrepreneurship and the Anderson Institute - Wayne State University". 2 August 2021. Archived from the original on 2021-06-13.
  2. ^ "Entrepreneurship and the Anderson Institute - Wayne State University". 2 August 2021. Archived from the original on 2021-04-16.
  3. ^ "Fellows of the IEEE, class of 2022" (PDF). Institute of Electrical and Electronics Engineers (IEEE). Archived from the original (PDF) on November 24, 2021.
  4. ^ "Wayne State University biotech startup Advaita receives prestigious NIH CAP award". Today@Wayne. 2018-05-15. Retrieved 2023-08-01.
  5. ^ Khatri, Purvesh; Draghici, Sorin; Ostermeier, G.Charles; Krawetz, Stephen A. (February 2002). "Profiling Gene Expression Using Onto-Express". Genomics. 79 (2): 266–270. doi:10.1006/geno.2002.6698. PMID 11829497.
  6. ^ Drăghici, Sorin; Khatri, Purvesh; Martins, Rui P.; Ostermeier, G.Charles; Krawetz, Stephen A. (February 2003). "Global functional profiling of gene expression☆☆This work was funded in part by a Sun Microsystems grant awarded to S.D., NIH Grant HD36512 to S.A.K., a Wayne State University SOM Dean's Post-Doctoral Fellowship, and an NICHD Contraception and Infertility Loan to G.C.O. Support from the WSU MCBI mode is gratefully appreciated". Genomics. 81 (2): 98–104. doi:10.1016/S0888-7543(02)00021-6. PMID 12620386.
  7. ^ Draghici, S.; Khatri, P.; Tarca, A. L.; Amin, K.; Done, A.; Voichita, C.; Georgescu, C.; Romero, R. (2007-09-04). "A systems biology approach for pathway level analysis". Genome Research. 17 (10): 1537–1545. doi:10.1101/gr.6202607. ISSN 1088-9051. PMC 1987343. PMID 17785539.
  8. ^ Donato, Michele; Xu, Zhonghui; Tomoiaga, Alin; Granneman, James G.; MacKenzie, Robert G.; Bao, Riyue; Than, Nandor Gabor; Westfall, Peter H.; Romero, Roberto; Draghici, Sorin (November 2013). "Analysis and correction of crosstalk effects in pathway analysis". Genome Research. 23 (11): 1885–1893. doi:10.1101/gr.153551.112. ISSN 1088-9051. PMC 3814888. PMID 23934932.
  9. ^ Tarca, Adi Laurentiu; Draghici, Sorin; Bhatti, Gaurav; Romero, Roberto (December 2012). "Down-weighting overlapping genes improves gene set analysis". BMC Bioinformatics. 13 (1): 136. doi:10.1186/1471-2105-13-136. ISSN 1471-2105. PMC 3443069. PMID 22713124.
  10. ^ Hanoudi, Samer; Donato, Michele; Draghici, Sorin (2017-05-09). Escriva, Hector (ed.). "Identifying biologically relevant putative mechanisms in a given phenotype comparison". PLOS ONE. 12 (5): e0176950. Bibcode:2017PLoSO..1276950H. doi:10.1371/journal.pone.0176950. ISSN 1932-6203. PMC 5423614. PMID 28486531.
  11. ^ Nguyen, Tuan-Minh; Shafi, Adib; Nguyen, Tin; Draghici, Sorin (December 2019). "Identifying significantly impacted pathways: a comprehensive review and assessment". Genome Biology. 20 (1): 203. doi:10.1186/s13059-019-1790-4. ISSN 1474-760X. PMC 6784345. PMID 31597578.
  12. ^ Nguyen, Tin; Tagett, Rebecca; Donato, Michele; Mitrea, Cristina; Draghici, Sorin (2016-02-01). "A novel bi-level meta-analysis approach: applied to biological pathway analysis". Bioinformatics. 32 (3): 409–416. doi:10.1093/bioinformatics/btv588. ISSN 1367-4803. PMC 5006307. PMID 26471455.
  13. ^ Nguyen, Tin; Diaz, Diana; Draghici, Sorin (2016-10-02). "TOMAS". Proceedings of the 7th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics. Seattle WA USA: ACM. pp. 13–22. doi:10.1145/2975167.2975168. ISBN 978-1-4503-4225-4.
  14. ^ Nguyen, Tin; Mitrea, Cristina; Tagett, Rebecca; Draghici, Sorin (March 2017). "DANUBE: Data-Driven Meta-ANalysis Using UnBiased Empirical Distributions—Applied to Biological Pathway Analysis". Proceedings of the IEEE. 105 (3): 496–515. doi:10.1109/JPROC.2015.2507119. ISSN 0018-9219. PMC 5919277. PMID 29706661.
  15. ^ Shafi, Adib; Nguyen, Tin; Peyvandipour, Azam; Draghici, Sorin (2019-07-22). Kelso, Janet (ed.). "GSMA: an approach to identify robust global and test Gene Signatures using Meta-Analysis". Bioinformatics. 36 (2): 487–495. doi:10.1093/bioinformatics/btz561. ISSN 1367-4803. PMC 7869776. PMID 31329248.
  16. ^ Shafi, Adib; Nguyen, Tin; Peyvandipour, Azam; Nguyen, Hung; Draghici, Sorin (2019-03-19). "A Multi-Cohort and Multi-Omics Meta-Analysis Framework to Identify Network-Based Gene Signatures". Frontiers in Genetics. 10: 159. doi:10.3389/fgene.2019.00159. ISSN 1664-8021. PMC 6434849. PMID 30941158.
  17. ^ Nguyen, Tin; Shafi, Adib; Nguyen, Tuan-Minh; Schissler, A. Grant; Draghici, Sorin (December 2020). "NBIA: a network-based integrative analysis framework – applied to pathway analysis". Scientific Reports. 10 (1): 4188. Bibcode:2020NatSR..10.4188N. doi:10.1038/s41598-020-60981-9. ISSN 2045-2322. PMC 7060280. PMID 32144346.
  18. ^ Saberian, Nafiseh; Peyvandipour, Azam; Donato, Michele; Ansari, Sahar; Draghici, Sorin (2019-10-01). Kelso, Janet (ed.). "A new computational drug repurposing method using established disease–drug pair knowledge". Bioinformatics. 35 (19): 3672–3678. doi:10.1093/bioinformatics/btz156. ISSN 1367-4803. PMC 6761937. PMID 30840053.
  19. ^ Peyvandipour, Azam; Saberian, Nafiseh; Shafi, Adib; Donato, Michele; Draghici, Sorin (2018-08-15). Valencia, Alfonso (ed.). "A novel computational approach for drug repurposing using systems biology". Bioinformatics. 34 (16): 2817–2825. doi:10.1093/bioinformatics/bty133. ISSN 1367-4803. PMC 6084573. PMID 29534151.
  20. ^ "NSF Award Search: Simple Search Results".
  21. ^ "Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results".
  22. ^ "Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results".
  23. ^ "Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results".
  24. ^ "Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results".
  25. ^ "Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results".
  26. ^ "Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results".
  27. ^ "Google Scholar". Google Scholar. Retrieved 29 November 2016.
  28. ^ "Sorin Draghici (0000-0002-0786-8377)". orcid.org.
  29. ^ https://www.amazon.com/Statistics-Microarrays-Bioconductor-Mathematical-Computational/dp/1439809771/ref=sr_1_2?crid=1Z4XFANL3G3PI&keywords=sorin+draghici&qid=1689793457&sprefix=sorin+draghici%2Caps%2C237&sr=8-2
  30. ^ https://www.amazon.com/Data-Analysis-Tools-DNA-Microarrays/dp/1584883154/ref=sr_1_1?crid=1Z4XFANL3G3PI&keywords=sorin+draghici&qid=1689793488&sprefix=sorin+draghici%2Caps%2C237&sr=8-1
  31. ^ "About TCBB • IEEE Computer Society".
  32. ^ Baxevanis, Andreas D. (2002). Bateman, Alex; Pearson, William R; Stein, Lincoln D; Stormo, Gary D; Yates, John R (eds.). Current Protocols in Bioinformatics. CiteSeerX 10.1.1.419.8061. doi:10.1002/0471250953. ISBN 9780471250951.
  33. ^ "BioMed Research International: Bioinformatics".
  34. ^ "Editorial Board of DISCOVERIES and DISCOVERIES REPORTS".

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