Mount Slesse was first climbed on August 10, 1927, by Stan Henderson, Mills Winram, and Fred Parkes, via a route starting from Slesse Creek. The standard route today is the Southwest Route, which involves approximately 1,650 m (5,413 ft) of ascent, a good deal of scrambling and some sections of technical rock climbing up to class 5.6. However Slesse is most famous for the Northeast Buttress, first climbed on August 28, 1963 by Fred Beckey, Steve Marts, and Eric Bjornstad. It is a serious multi-day rock climb (Grade V) with technical difficulty of class 5.8 or 5.9.[2] This climb is featured in Roper and Steck's Fifty Classic Climbs of North America. In July 1966 Hans Baer and Jack Bryan did the second ascent of this route, with one bivouac and a straight line exit at the top of the buttress. Climbers come to the Fraser Valley from around the world to climb the aesthetic 24 pitch granite spire, making it one of the most iconic climbs in North America. While the original ascents of Mt. Slesse were multi-day excursions, most modern climbing parties climb the route in a single day.
On December 9, 1956, Trans-Canada Air Lines Flight 810, a North Star airplane crashed on the upper slopes of the mountain, killing all 62 people aboard.[6] This was one of the world's worst air disasters up to that time. Prominent among the dead were team members of the Winnipeg Blue Bombers and Saskatchewan Roughriders, on their way home from the annual East-West All-Star Game in Vancouver.[7][8] A memorial to the dead can be found on a spur road just above the Chilliwack River Road. The site itself was supposed to have been consecrated by the Cemeteries Act after the discovery of the crash site and associated human remains, some of which were gathered into a common grave. Others found by climbers and hikers have been placed in a "shrine" out of the weather in a discreet location. In the 1990s the provincial government, under pressure from the Families of Slesse organization, finally passed legislation to enshrine protection of the site, which was under threat from clearcut logging at the time, and markers have been placed on trails leading into the site requesting it be respected by hikers and others accessing it.