Since its opening in 1987, this joint project between the City of Cape Girardeau and the university annually hosts approximately 250 meeting room and 160 arena events as an entertainment, meeting, and gathering center. It replaced Houck Field House as the primary home of Southeast Missouri State's athletics teams.
In 2015 the Show Me Center underwent a $5.62 million upgrade. The changes included: new scoreboards and shot clocks, a center-hung video display, new seating in the lower section, an improved audio system, and LED lighting above the court.[3]
The arena has hosted several nationally televised professional wrestling events in its history, including the WWF in April 1988 and WCW in January 2000. A 2011 house show at the venue was mentioned in an episode of WWE Story Time on the WWE Network.