Macdonald has been a practicing artist since the mid-1990s. Since 2013 she has made paintings of reflected rain in various guises. Between 2013 and 2017, her work exhibited metaphorical associations of inversion and reflection, such as states of disorientation. In 2018, she shifted focus by 'zooming in' closer, capturing raindrops circling onto groundwater. These newer paintings fracture previously legible images into ripples. Originating in drawing and photography, she engages with analog and digital, moving between collage, photocopies, projections, tracings, and drawing. She then uses paint diluted with stand oil and neo-megilp on neutral-toned linen creating a sheen that emulates the surface of water.
Macdonald makes drawings inspired by row coverings and cold frames dotted around the local Western Massachusetts landscape. She uses both small, intimate (5 in. x 9 in.) and large, physical (up to 8 feet wide) scales in her work. Her current (as of 2020) painting series are titled Sky on Ground and Ground Covering, where "ground" is both a noun and a verb: the earth beneath our feet, and the act of anchoring and situating a body in place.
Her work is influenced by many sources including the Kano School, particularly the work of Kano Tanyu, Latvian artist Vija Celmins, and Chicago artist and former professor Julia Fish.
Since 2008, Macdonald has been represented by Cynthia-Reeves Gallery in New Hampshire.
Macdonald moved to New England in 2006.[2] She lives and works in Massachusetts. She is married to Eric Salus and has three children: daughter, Isla Salus, and sons, Bram and Fenno Salus.