The Senio is a river in Italy. Senio may also refer to:

• Senio Kelemete (born 1990), American football player
• Senio Toleafoa (born 1993), Australian rugby union player
• John Senio (born 1982), Samoan rugby union player
• Kevin Senio (born 1978), New Zealand rugby union player

• Palazzuolo sul Senio, commune in Italy

This disambiguation page lists articles associated with the title Senio.
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