The Second Ministry of Machine Building (第二机械工业部) was a government ministry of the People's Republic of China which oversaw the nuclear industry of China.

It was established in August 1952. In April 1988 it became part of the newly (now former) created Ministry of Energy Resources.

• First Ministry of Machine-Building of the PRC
• Third Ministry of Machine-Building of the PRC, ministry of aviation industry
• Fourth Ministry of Machine-Building of the PRC, ministry of electronics industry
• Fifth Ministry of Machine-Building of the PRC, ministry of tank equipment and artillery
• Sixth Ministry of Machine-Building of the PRC, ministry of shipbuilding
• Seventh Ministry of Machine-Building of the PRC, ministry of space industry
• Eighth Ministry of Machine-Building of the PRC

• Malcolm Lamb: Directory of officials and Organizations in China, ME Sharpe Inc. Armonk, NY, 2003, p. 1911 +, ISBN 0-7656-1020-5, Volume 1
• China's Economic System, Routledge Abingdon 2005, 594 p., ISBN 0-415-36147-8