Santa María Mixtequilla
Municipality and town
Santa María Mixtequilla Location in Mexico
Coordinates: 16°22′N 95°15′W / 16.367°N 95.250°W / 16.367; -95.250
Country	Mexico
State	Oaxaca
Time zone	UTC-6 (Central Standard Time)
• Summer (DST)	UTC-5 (Central Daylight Time)

Santa María Mixtequilla is a town and municipality in Oaxaca in south-western Mexico. The municipality covers an area of km². It is part of the Tehuantepec District in the west of the Istmo Region.

As of 2010, the municipality had a total population of 3,638.^[1]

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