The city of Santa Lucía del Camino had a 2005 census population of 42,570 and serves as the municipal seat of the municipality of Santa Lucía del Camino, which has an area of 9.437 km² (2.95 sq mi) and a population of 45,752. The only other community in the small municipality is the town of San Francisco Tutla (population 3,182). The city is the seventh-largest community in the state of Oaxaca in population.
As municipal seat, Santa Lucia del Camino has governing jurisdiction over the village of San Francisco Tutla as well as itself.