Sant'Andrea del Garigliano is a comune (municipality) in the Province of Frosinone in the Italian region Lazio, located about 130 kilometres (81 miles) southeast of Rome and about 50 km (31 mi) southeast of Frosinone.
Sant'Andrea del Garigliano borders the following municipalities: Castelforte, Rocca d'Evandro, Sant'Ambrogio sul Garigliano, Sant'Apollinare, Vallemaio.
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