San Sebastiano Curone (Piedmontese: San Bastiau Curou ) is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 110 kilometres (68 mi) southeast of Turin and about 40 kilometres (25 mi) southeast of Alessandria, at the confluence of the Curone and Museglia streams.
Part of the commune of Fabbrica Curone it was under the dominations of the Malaspina and Fieschi from Genoa. In the 16th century, under the Doria, it became an important market centre for salt, fish and cereals.
It is the birthplace of Felice Giani, a neo-classicist painter.
